Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel.

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY
International Journal of Nanomedicine Pub Date : 2024-11-08 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S486640
Jing Yang, Donghui Jia, Jialu Qiao, Ximing Peng, Chuchao Zhou, Yanqing Yang
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引用次数: 0

Abstract

Introduction: The photo-activated thermo/gas antimicrobial nanocomposite hydrogel, Gel/PDA@BNN6, is composed of the nitric oxide (NO) carrier N, N'-di-sec-butyl-N, N'-dinitroso-p-phenylenediamine (BNN6), photothermal (PTT) material polydopamine nanoparticles (PDA NPs), and methacrylate gelatin (GelMA). This hydrogel can release NO gas in a stable and controlled manner, generating a localized photothermal effect when exposed to near-infrared laser light. This dual action promotes the healing of full-thickness skin wounds that are infected.

Methods: Gel/PDA@BNN6 was developed, and both in vitro and in vivo experiments were carried out to evaluate its structure, physicochemical properties, antibacterial effects, effectiveness in promoting infected wound healing, and biocompatibility.

Results: Gel/PDA@BNN6 was successfully synthesized, exhibiting a porous three-dimensional lattice structure and excellent mechanical properties. It demonstrated highly efficient photothermal conversion, controllable nitric oxide delivery, strong bactericidal effects, and minimal cytotoxicity in vitro. In vivo, Gel/PDA@BNN6, when used with NIR therapy, showed significant anti-inflammatory effects, promoted collagen deposition, and stimulated vascular neoangiogenesis, which accelerated wound closure. Additionally, it displayed superior biocompatibility.

Discussion: Gel/PDA@BNN6 has shown an explicit curative effect for infected wound healing, suggesting it has a good chance of being an antimicrobial dressing in the future.

用于增强感染性伤口愈合的可控一氧化氮释放纳米颗粒:包裹在 GelMA 水凝胶中的 PDA@BNN6 研究。
导言:光激活热/气抗菌纳米复合水凝胶 Gel/PDA@BNN6 由一氧化氮(NO)载体 N,N'-二仲丁基-N,N'-二亚硝基对苯二胺(BNN6)、光热(PTT)材料聚多巴胺纳米颗粒(PDA NPs)和甲基丙烯酸酯明胶(GelMA)组成。这种水凝胶能以稳定、可控的方式释放氮氧化物气体,并在近红外激光照射下产生局部光热效应。这种双重作用可促进受感染的全厚皮肤伤口的愈合:方法:开发了凝胶/PDA@BNN6,并对其结构、理化性质、抗菌效果、促进感染伤口愈合的有效性以及生物相容性进行了体外和体内实验:结果:成功合成了凝胶/PDA@BNN6,它具有多孔的三维晶格结构和优异的机械性能。它在体外表现出高效的光热转换、可控的一氧化氮输送、强大的杀菌作用和最小的细胞毒性。在体内,Gel/PDA@BNN6 与近红外疗法一起使用时,显示出显著的抗炎效果,促进胶原蛋白沉积,刺激血管新生,从而加速伤口闭合。此外,它还具有良好的生物相容性:讨论:凝胶/PDA@BNN6 对感染性伤口愈合有明显的治疗效果,这表明它很有可能在未来成为一种抗菌敷料。
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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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