Clinical Characteristics and Predictors of Mortality of Patients with Post-Neurosurgical Meningitis-A 900-Cases Cohort Study.

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI:10.2147/IDR.S491379

Guanghui Zheng, Yijun Shi, Jialu Sun, Siqi Wang, Lingye Qian, Hong Lv, Guojun Zhang, Kelin Chen

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引用次数: 0

Abstract

Aim: To express the clinical characteristics of patients with post-neurosurgical meningitis (PNM) and launch a survival analysis to screen mortality predictors.

Methods: A cohort analysis containing more than 70000 patients was evaluated, and all of them received neurosurgical procedure. Clinical and microbial epidemiology, therapy and mortality of PNM patients were reviewed. Multi-variable Cox proportional hazard models were applied to achieve survival analysis.

Results: About 900 PNM patients from 3244 cases were selected for characteristics and survival analysis, the mean age of them was 41 (27-54) years, 516 (57.3%) were men and 384 (42.7%) were women. The 28-day mortality was 12.4% (112 of 900) in patients with PNM. Hypertension, external ventricular drainage (EVD), and lumbar drainage (LD) are mortality predictors for PNM, with a hazard ratio (HR) of 2.641 (95% C.I. 1.563-4.464, P<0.001), 2.196 (95% C.I. 1.317-3.662, P=0.003), and 1.818 (95% C.I. 1.126-2.936, P=0.014). In treatment, the outcome of patients receiving three or more antibiotic combinations is better than that of patients receiving dual-drug combinations.

Conclusion: The mortality of patients with PNM was relatively high, and the risk factors related to 28-days mortality were hypertension, EVD and LD and treatment with three or more antibiotics are much better.

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神经外科手术后脑膜炎患者的临床特征和死亡率预测因素--一项 900 例队列研究。

目的：表达神经外科手术后脑膜炎（PNM）患者的临床特征，并开展生存分析以筛选死亡率预测因素：方法：对包含 7 万多名患者的队列分析进行评估，所有患者均接受过神经外科手术。研究回顾了脑膜炎患者的临床和微生物流行病学、治疗和死亡率。应用多变量 Cox 比例危险模型进行生存分析：从 3244 例 PNM 患者中选取了约 900 例进行特征和生存分析，他们的平均年龄为 41（27-54）岁，其中 516 例（57.3%）为男性，384 例（42.7%）为女性。PNM患者的28天死亡率为12.4%（900例中有112例）。高血压、心室外引流（EVD）和腰椎引流（LD）是预测 PNM 死亡率的因素，其危险比（HR）为 2.641（95% C.I. 1.563-4.464, PC结论）：PNM患者的死亡率相对较高，与28天死亡率相关的危险因素是高血压、EVD和LD，使用三种或三种以上抗生素治疗的效果更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.