Weight status change during four years and left ventricular hypertrophy in Chinese children.

IF 2.1 3区医学 Q2 PEDIATRICS

Frontiers in Pediatrics Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1371286

Qin Liu, Cheng Li, Lili Yang, Zhuo Gong, Min Zhao, Pascal Bovet, Bo Xi

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引用次数: 0

Abstract

Objective: It is well-established that overweight/obesity is a major risk factor for left ventricular hypertrophy (LVH) in childhood. However, it is still unclear if reversing from overweight/obesity to normal weight is associated with decreased LVH in children. This study aimed to examine the association between weight status change during four years and LVH among Chinese children based on a prospective cohort study.

Methods: Data were obtained from the Huantai Childhood Cardiovascular Health Cohort Study in China. A total of 1,178 children without LVH at baseline (mean age: 8.3 years) were included in this study. According to weight status [normal weight or overweight (including obesity)] at baseline (2017) and follow-up (2021), children were divided, based on sex- and age-adjusted body mass index (BMI), into four groups: persistent normal weight (normal weight at both baseline and follow-up), incident overweight (normal weight at baseline but overweight at follow-up), reversal to normal weight (overweight at baseline but normal weight at follow-up), persistent overweight (overweight at both baseline and follow-up).

Results: After adjustment for potential confounding factors, children with incident overweight (n = 114, 30.63 ± 4.74 g/m^2.7) and those with persistent overweight (n = 363, 31.56 ± 6.24 g/m^2.7) had higher left ventricular mass index (LVMI) at the end of the follow-up period than those with persistent normal weight (n = 632, 28.46 ± 7.64 g/m^2.7), while those who reversed from overweight to normal weight had a non-significantly lower LVMI (n = 69, 28.51 ± 4.28 g/m^2.7). Compared to children with persistent normal weight, those with persistent overweight [odds ratio (OR) = 5.14, 95% confidence interval (CI) = 3.33-7.95] and those with incident overweight (OR = 3.34, 95% CI = 1.77-6.30) had an increased risk of LVH. The risk of LVH tended to decrease, although not significantly, in those who reversed from overweight to normal weight (OR = 0.76, 95% CI = 0.22-2.55).

Conclusion: Our findings demonstrate a positive association between overweight and left ventricular mass in children and suggest that LVH in childhood could be attenuated by weight loss.

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中国儿童四年间的体重变化与左心室肥厚。

目的：超重/肥胖是儿童左心室肥厚（LVH）的主要风险因素，这一点已得到公认。然而，从超重/肥胖转为正常体重是否与儿童左心室肥厚的减少有关，目前仍不清楚。本研究旨在通过一项前瞻性队列研究，探讨中国儿童四年内体重变化与左心室肥厚之间的关系：方法：数据来自中国桓台儿童心血管健康队列研究。本研究共纳入 1,178 名基线时无 LVH 的儿童（平均年龄：8.3 岁）。根据基线（2017年）和随访（2021年）时的体重状况[正常体重或超重（包括肥胖）]，将儿童按性别和年龄调整后的体重指数（BMI）分为四组：持续正常体重组（基线和随访时体重均正常）、偶发超重组（基线时体重正常但随访时超重）、逆转为正常体重组（基线时超重但随访时体重正常）、持续超重组（基线和随访时体重均超重）：结果：在对潜在的混杂因素进行调整后，发生超重的儿童（n = 114，30.63 ± 4.74 g/m2.7）和持续超重的儿童（n = 363，31.56 ± 6.24 g/m2.7）的左心室容量较高。7）在随访期结束时的左心室质量指数（LVMI）高于体重持续正常的儿童（n = 632，28.46 ± 7.64 g/m2.7），而从超重转为正常体重的儿童的左心室质量指数（LVMI）则无显著降低（n = 69，28.51 ± 4.28 g/m2.7）。与体重持续正常的儿童相比，体重持续超重的儿童[比值比（OR）=5.14，95% 置信区间（CI）=3.33-7.95]和体重意外超重的儿童（OR = 3.34，95% CI = 1.77-6.30）罹患左心室肥厚的风险增加。从超重转为正常体重的人群发生左心室肥厚的风险呈下降趋势，但并不明显（OR = 0.76，95% CI = 0.22-2.55）：我们的研究结果表明，儿童超重与左心室质量之间存在正相关，并表明儿童左心室肥厚可通过减轻体重而得到缓解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.