Global burden of multiple sclerosis and its attributable risk factors, 1990-2019.

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Frontiers in Neurology Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI:10.3389/fneur.2024.1448377

Saeid Safiri, Amir Ghaffari Jolfayi, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Mark J M Sullman, Ali-Asghar Kolahi

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Abstract

Background: Multiple sclerosis (MS) is a progressively debilitating disorder that has seen a notable rise in prevalence in recent years. This study examines the burden of MS from 1990 to 2019, providing a detailed analysis by age, sex, and sociodemographic index (SDI) across 204 countries and territories.

Methods: Data on the prevalence, death and disability-adjusted life years (DALYs) attributable to MS were obtained from the publically available Global Burden of Disease 2019 project. The estimates are reported as numbers, percentages, and age-standardized rates per 100,000, accompanied by 95% uncertainty intervals.

Results: In 2019, MS accounted for 1.8 million prevalent cases, 22.4 thousand deaths and 1.2 million DALYs worldwide. There were significant declines in the global age-standardized prevalence, mortality and DALY rates of MS over the period 1990-2019. In 2019, females exhibited a higher global point prevalence and a greater total number of prevalent MS cases than males across all age groups. At the regional level, a non-linear relationship was observed between the age-standardized DALY rate of MS and SDI.

Conclusion: Although the global age-standardized DALY rate of MS decreased between 1990 and 2019, MS continues to account for a considerable number of DALYs and prevalent cases. Integrating MS and its associated risk factors into healthcare planning is vital, especially in areas with high levels of socioeconomic development.

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1990-2019 年全球多发性硬化症负担及其可归因风险因素。

背景：多发性硬化症（MS）是一种使人逐渐衰弱的疾病，近年来发病率明显上升。本研究探讨了 1990 年至 2019 年多发性硬化症造成的负担，按年龄、性别和社会人口指数（SDI）对 204 个国家和地区进行了详细分析：方法：多发性硬化症的发病率、死亡率和残疾调整生命年（DALYs）数据来自公开发布的《2019 年全球疾病负担》项目。估计值以数字、百分比和每十万人的年龄标准化比率的形式报告，并附有95%的不确定性区间：2019年，多发性硬化症在全球的发病人数为180万，死亡人数为2.24万，残疾调整生命年数为120万。1990-2019年期间，多发性硬化症的全球年龄标准化患病率、死亡率和残疾调整寿命年率均出现大幅下降。2019 年，在所有年龄组中，女性的全球点流行率和多发性硬化症病例总数均高于男性。在地区层面，多发性硬化症的年龄标准化残疾调整寿命年率与 SDI 之间存在非线性关系：尽管在 1990 年至 2019 年期间，全球多发性硬化症的年龄标准化残疾调整寿命年数率有所下降，但多发性硬化症仍然造成了相当数量的残疾调整寿命年数和流行病例。将多发性硬化症及其相关风险因素纳入医疗保健规划至关重要，尤其是在社会经济发展水平较高的地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neurology CLINICAL NEUROLOGYNEUROSCIENCES -NEUROSCIENCES

CiteScore

4.90

自引率

8.80%

发文量

2792

审稿时长

14 weeks

期刊介绍： The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.