Chemokine profile in the serum of patients with leptospirosis.

IF 4.6 2区 医学 Q2 IMMUNOLOGY
Frontiers in Cellular and Infection Microbiology Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI:10.3389/fcimb.2024.1484291
Iago H de Miranda Mariano, Roberta M Blanco, Camila Eulalio de Souza, Geovanna Silva de Freitas, Paulo Lee Ho, Elizabeth A L Martins, Eliete C Romero, Josefa B da Silva
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引用次数: 0

Abstract

Introduction: Leptospirosis is a global zoonosis that affects more than one million people per year, with a lethality rate of approximately 15%. Chemokines are crucial in the immune response against Leptospira, recruiting leukocytes to the site of infection and regulating immune activity. In previous studies, we have shown that CCL2, CXCL5, and CCL8 are involved in the leptospirosis process, although the mechanisms are not understood.

Methods: In this study, we present the frequency of Leptospira serovars in human samples. We then evaluated the profile of various chemokines in sera from patients diagnosed with leptospirosis, assessing the possible correlation between them. Moreover, we evaluated the changes in the chemokine profile on different days after the first symptoms. The frequency of the Leptospira serovars in human samples is presented.

Results and discussion: The main findings were that CCL5, CXCL5, and CXCL9 are highly expressed during leptospirosis, indicating a special role of these molecules in the immunity and pathogenesis of the disease. The correlation analysis of detected chemokines CXCL11, CXCL9, CCL3, and CCL2 helps to clarify the role of each cytokine in leptospirosis. The possible use of CCL5 as a biomarker for complementary diagnosis of the disease is suggested.

钩端螺旋体病患者血清中的趋化因子谱。
导言:钩端螺旋体病是一种全球性的人畜共患疾病,每年有 100 多万人感染,致死率约为 15%。趋化因子在针对钩端螺旋体的免疫反应中至关重要,它能将白细胞募集到感染部位并调节免疫活性。在之前的研究中,我们已经发现 CCL2、CXCL5 和 CCL8 参与了钩端螺旋体病的发病过程,但其机制尚不清楚:在本研究中,我们介绍了钩端螺旋体血清型在人体样本中的出现频率。然后,我们评估了确诊为钩端螺旋体病患者血清中各种趋化因子的概况,评估了它们之间可能存在的相关性。此外,我们还评估了首次出现症状后不同日子里趋化因子谱的变化。结果和讨论:主要发现是,CCL5、CXCL5 和 CXCL9 在钩端螺旋体病期间高表达,表明这些分子在免疫和疾病发病机制中的特殊作用。对检测到的趋化因子 CXCL11、CXCL9、CCL3 和 CCL2 的相关性分析有助于明确每种细胞因子在钩端螺旋体病中的作用。建议将 CCL5 用作辅助诊断该疾病的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.90
自引率
7.00%
发文量
1817
审稿时长
14 weeks
期刊介绍: Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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