The role of neuropeptides in cutaneous wound healing: a focus on mechanisms and neuropeptide-derived treatments.

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in Bioengineering and Biotechnology Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.3389/fbioe.2024.1494865
Liwei Xing, Bing Chen, Yuliang Qin, Xinyao Li, Sitong Zhou, Kai Yuan, Rong Zhao, Dongdong Qin
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Abstract

An extensive network of cutaneous nerves, neuropeptides, and specific receptors richly innervates the skin and influences a variety of physiological and pathological processes. The sensory and autonomic nerve fibers secrete a variety of neuropeptides that are essential to the different phases of wound healing. In addition to initiating a neurogenic inflammatory response in the early stages of healing, neuropeptides also control wound healing by influencing immune cells, repair cells, and the growth factor network. However, the precise mechanism by which they accomplish these roles in the context of cutaneous wound healing is still unknown. Investigating the mechanisms of action of neuropeptides in wound healing and potential therapeutic applications is therefore urgently necessary. The present review discusses the process of wound healing, types of neuropeptides, potential mechanisms underlying the role of neuropeptides in cutaneous wound healing, as well as some neuropeptide-derived treatment strategies, such as hydrogels, new dressings, electro stimulation, and skin-derived precursors. Future in-depth mechanistic studies of neuropeptides in cutaneous wound healing may provide opportunities to develop therapeutic technologies that harness the roles of neuropeptides in the wound healing process.

神经肽在皮肤伤口愈合中的作用:关注机制和神经肽衍生疗法。
广泛的皮肤神经网络、神经肽和特异性受体丰富地支配着皮肤,并影响着各种生理和病理过程。感觉和自主神经纤维会分泌多种神经肽,这些神经肽对伤口愈合的不同阶段至关重要。除了在伤口愈合的早期阶段启动神经源性炎症反应外,神经肽还通过影响免疫细胞、修复细胞和生长因子网络来控制伤口愈合。然而,神经肽在皮肤伤口愈合中发挥这些作用的确切机制尚不清楚。因此,迫切需要研究神经肽在伤口愈合中的作用机制和潜在的治疗应用。本综述讨论了伤口愈合的过程、神经肽的类型、神经肽在皮肤伤口愈合中发挥作用的潜在机制,以及一些神经肽衍生的治疗策略,如水凝胶、新型敷料、电刺激和皮肤衍生前体。未来对神经肽在皮肤伤口愈合中的作用进行深入的机理研究,可能会为开发利用神经肽在伤口愈合过程中的作用的治疗技术提供机会。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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