Vincent Lok, Sy Olson-McPeek, Grace Spiegelhoff, Jaqueline Cortez, David Detz, Brian Czerniecki
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引用次数: 0
Abstract
Introduction: Immunotherapies have found limited success in breast cancerdue to significant challenges within the tumor that block T-cell activity and function.
Areas covered: The current review discusses clinically relevant immunotherapeutics and trials within the framework of the cancer-immunity cycle.
Expert opinion: Current therapies such as antibody-drug conjugates and immune checkpoint blockade require proper biomarker selection, such as PD1 expression and the degree of tumor-infiltrating lymphocyte (TIL) infiltration to subset potential responders. HER2 and other tumor-associated antigens have served as valuable benchmarks for developing novel therapies, such as antibody engagers and CAR T-cells. However, further research is essential to identify and validate new target antigens that can enhance therapeutic efficacy and broaden the clinical applicability of these approaches.
简介：免疫疗法在乳腺癌中的成功率有限，原因是肿瘤内部存在阻碍T细胞活性和功能的重大挑战：本综述在癌症-免疫循环的框架内讨论了临床相关的免疫疗法和试验：目前的疗法，如抗体药物共轭物和免疫检查点阻断，需要适当的生物标记物选择，如PD1表达和肿瘤浸润淋巴细胞（TIL）浸润程度，以细分潜在的应答者。HER2 和其他肿瘤相关抗原已成为开发新型疗法（如抗体激活剂和 CAR T 细胞）的重要基准。然而，进一步的研究对于确定和验证新的靶抗原至关重要，这些靶抗原可以提高疗效并扩大这些方法的临床适用性。
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