A systematic review of the implications of lipocalin-2 expression in periodontal disease.

Q3 Dentistry

Evidence-based dentistry Pub Date : 2024-11-08 DOI:10.1038/s41432-024-01070-y

Diana L Solís-Suárez, Saúl E Cifuentes-Mendiola, Ana L García-Hernández

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引用次数: 0

Abstract

Objective: Evidence suggests that lipocalin-2 (LCN-2), a bone-derived protein, is upregulated in periodontal diseases. This systematic review aimed to evaluate LCN-2 concentrations in individuals with periodontal diseases, identifying the most suitable body fluids for its detection, the type of periodontal disease with the highest LCN-2 expression, its association with other inflammatory markers and systemic diseases, and whether its expression can be modified by periodontal treatment.

Methods: A systematic search of Google Scholar, PubMed, and ProQuest up to August 2024 was conducted. The studies were screened and selected by the authors according to specific eligibility criteria. Quality assessment of the included studies was performed according to the study type using STROBE statement for observational studies or the modified Jadad scale for experimental studies. The review was registered in PROSPERO (CRD42023458565).

Results: In total, three thousand six hundred and thirty-eight reports were identified, of which twenty-seven were full-text assessed for eligibility, including eleven articles. Seven articles were observational, and four were experimental. Significantly elevated LCN-2 levels were reported in patients with periodontal disease across 9 studies, being higher in periodontitis rather than gingivitis. LCN-2 was mainly detected in gingival crevicular fluid (GCF) and saliva. LCN-2 expression is related to the increment of inflammatory markers, and periodontal therapy decreases LCN-2 concentrations. LCN-2 levels were aggravated when periodontitis was accompanied by obesity and type 2 diabetes.

Conclusion: LCN-2 is implicated in periodontal diseases, probably through the inflammation process.

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脂钙蛋白-2表达对牙周病影响的系统性综述。

目的：有证据表明，脂钙蛋白-2（LCN-2）是一种骨源性蛋白，在牙周疾病中上调。本系统综述旨在评估牙周病患者体内的 LCN-2 浓度，确定最适合检测 LCN-2 的体液、LCN-2 表达量最高的牙周病类型、LCN-2 与其他炎症标志物和全身性疾病的关系，以及牙周治疗是否能改变 LCN-2 的表达：方法：对截至 2024 年 8 月的 Google Scholar、PubMed 和 ProQuest 进行了系统检索。作者根据特定的资格标准对研究进行了筛选。根据研究类型对纳入的研究进行质量评估，对观察性研究采用 STROBE 声明，对实验性研究采用修改后的 Jadad 量表。综述已在 PROSPERO（CRD42023458565）上注册：结果：总共发现了三千六百三十八篇报告，其中二十七篇经过全文资格评估，包括十一篇文章。七篇为观察性文章，四篇为实验性文章。9项研究均报告牙周病患者的LCN-2水平显著升高，牙周炎患者的LCN-2水平高于牙龈炎患者。LCN-2 主要在牙龈缝隙液（GCF）和唾液中检测到。LCN-2 的表达与炎症标志物的增加有关，牙周治疗会降低 LCN-2 的浓度。当牙周炎伴有肥胖和 2 型糖尿病时，LCN-2 水平会升高：结论：LCN-2 可能通过炎症过程与牙周疾病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Evidence-based dentistry Dentistry-Dentistry (all)

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Evidence-Based Dentistry delivers the best available evidence on the latest developments in oral health. We evaluate the evidence and provide guidance concerning the value of the author''s conclusions. We keep dentistry up to date with new approaches, exploring a wide range of the latest developments through an accessible expert commentary. Original papers and relevant publications are condensed into digestible summaries, drawing attention to the current methods and findings. We are a central resource for the most cutting edge and relevant issues concerning the evidence-based approach in dentistry today. Evidence-Based Dentistry is published by Springer Nature on behalf of the British Dental Association.