The mediating role of serum 25-hydroxyvitamin D on the association between reduced sensitivity to thyroid hormones and periodontitis in Chinese euthyroid adults.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.3389/fendo.2024.1456217

Hao Yang, Yayun Lu, Lina Zhao, Yufeng He, Yuecheng He, Dong Chen

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引用次数: 0

Abstract

Aim: Thyroid dysfunction is closely associated with periodontitis. We aim to explore the association between sensitivity to thyroid hormones (THs) and periodontitis and to investigate the mediating role of serum 25-hydroxyvitamin D[25(OH)D] in this relationship in Chinese euthyroid populations.

Methods: This population-based retrospective study included 2,530 euthyroid participants. Central sensitivity to THs was assessed by the thyroid feedback quantile-based index (TFQI), parametric thyroid feedback quantile-based index (PTFQI), thyrotrophic thyroxine resistance index (TT4RI) and thyroid-stimulating hormone index (TSHI), while FT3/FT4 was evaluated to assess peripheral sensitivity. Multivariable regression analysis and restricted cubic spline were performed to explore the association between sensitivity to THs and periodontitis. Threshold effect and subgroup analysis were also conducted. Mediation analysis was performed to estimate direct and indirect effects through 25(OH)D.

Results: Multivariable regression analysis indicated that central sensitivity to THs indices(per SD increase) were positively associated with periodontitis risk [TFQI: OR=1.19,95% CI (1.09, 1.31); PTFQI: OR=1.22, 95% CI(1.12,1.34); TSHI: OR=1.36, 95% CI (1.21,1.52); TT4RI: OR=1.43, 95% CI (1.25,1.63)](all P value<0.001). TT4RI only had a non-linear relationship with periodontitis in euthyroid participants. Subgroup analysis showed that no significant correlations were founded among those aged over 65 years or with hypertension/diabetes. Mediation analysis revealed that the proportions mediated by 25(OH)D on the association of TFQI, PTFQI,TSHI, TT4RI and periodontitis risk were 16.37%, 16.43%, 9.93% and 10.21%, respectively.

Conclusions: Impaired central sensitivity to THs is positively associated with periodontitis in euthyroid and serum 25(OH)D might be one of its biological mechanisms.

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中国甲状腺功能正常成年人血清 25- 羟维生素 D 对甲状腺激素敏感性降低与牙周炎之间关系的中介作用。

目的：甲状腺功能障碍与牙周炎密切相关。我们旨在探讨中国甲状腺功能正常人群对甲状腺激素（THs）的敏感性与牙周炎之间的关系，并研究血清25-羟维生素D[25(OH)D]在这种关系中的中介作用：这项基于人群的回顾性研究包括 2,530 名甲状腺功能正常的参与者。通过甲状腺反馈量子化指数（TFQI）、参数甲状腺反馈量子化指数（PTFQI）、甲状腺营养性甲状腺素抵抗指数（TT4RI）和促甲状腺激素指数（TSHI）评估对THs的中枢敏感性，同时评估FT3/FT4以评估外周敏感性。采用多变量回归分析和限制性立方样条曲线来探讨甲状腺激素敏感性与牙周炎之间的关系。此外，还进行了阈值效应和亚组分析。还进行了中介分析，以估计通过 25(OH)D 产生的直接和间接影响：多变量回归分析表明，中心对 THs 的敏感性指数（每标准差增加）与牙周炎风险呈正相关[TFQI：OR=1.19，95% CI (1.09,1.31)；PTFQI：OR=1.22，95% CI (1.12,1.34)；TSHI：OR=1.36，95% CI (1.21,1.52)；TT4RI：OR=1.43，95% CI (1.25,1.63)]（均为 P 值）：甲状腺功能正常者对THs的中枢敏感性受损与牙周炎呈正相关，而血清25（OH）D可能是其生物学机制之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.