Immunohistochemical markers in the determination of lesion viability in decomposed bodies: A mini literature review

IF 2.2 3区医学 Q1 MEDICINE, LEGAL

Forensic science international Pub Date : 2024-11-05 DOI:10.1016/j.forsciint.2024.112289

Cecilia Salzillo , Liliana Innamorato , Alessia Leggio , Andrea Marzullo

引用次数: 0

Abstract

The ability to distinguish between viable and post-mortem lesions is crucial in forensic medicine, especially in cases of advanced decomposition. Glycophorin A (GPA) is one of the most studied immunohistochemical markers for assessing lesion viability, with persistence in putrefied tissues up to 6 months. However, its sensitivity decreases beyond 15 days. Other markers such as tryptase, IL-15, CD15, CD45 and matrix metalloproteinases have been tested in decomposition contexts, but the results are inconclusive. This mini review article explores the main studies on immunohistochemical markers, discussing their utility and limitations in forensic investigations of decomposed bodies.

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免疫组化标记在确定腐尸病变存活率中的作用：小型文献综述。

在法医学中，尤其是在晚期腐烂的情况下，区分存活病变和死后病变的能力至关重要。Glycophorin A（GPA）是研究最多的评估病变存活能力的免疫组化标记物之一，在腐败组织中的存活时间长达 6 个月。不过，超过 15 天后，其敏感性就会下降。其他标记物，如胰蛋白酶、IL-15、CD15、CD45 和基质金属蛋白酶也在分解过程中进行了测试，但结果并不确定。这篇小型综述文章探讨了有关免疫组化标记物的主要研究，讨论了这些标记物在法医调查腐烂尸体时的作用和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Forensic science international 医学-医学：法

CiteScore

5.00

自引率

9.10%

发文量

285

审稿时长

49 days

期刊介绍： Forensic Science International is the flagship journal in the prestigious Forensic Science International family, publishing the most innovative, cutting-edge, and influential contributions across the forensic sciences. Fields include: forensic pathology and histochemistry, chemistry, biochemistry and toxicology, biology, serology, odontology, psychiatry, anthropology, digital forensics, the physical sciences, firearms, and document examination, as well as investigations of value to public health in its broadest sense, and the important marginal area where science and medicine interact with the law. The journal publishes: Case Reports Commentaries Letters to the Editor Original Research Papers (Regular Papers) Rapid Communications Review Articles Technical Notes.