Relationship between HECTD4 gene variants, obesity, and coffee consumption.

IF 3.6 3区医学 Q2 NUTRITION & DIETETICS

European Journal of Clinical Nutrition Pub Date : 2024-11-09 DOI:10.1038/s41430-024-01541-6

Min-Jeong Kim, Hyun-Seok Jin, Yong-Bin Eom

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引用次数: 0

Abstract

Background: In genome-wide association studies, the HECT domain E3 ubiquitin-protein ligase 4 (HECTD4) gene was suggested to be associated with obesity-related traits and coffee consumption. However, the association of genetic variants between coffee consumption and obesity has not been tested in Koreans. Therefore, we investigated whether HECTD4 gene variants act as effect modifiers on the relationship between obesity and coffee.

Methods: This study analyzed the correlation between coffee consumption and obesity among 58,698 individuals representing the Health Examinees. Participants were categorized into obese (BMI ≥ 25.0 kg/m²) and nonobese (18.5 ≤ BMI < 23.0 kg/m²). Food consumption was assessed by a food frequency questionnaire.

Results: We identified four HECTD4 gene variants associated with obesity-related traits and coffee consumption based on Bonferroni-corrected significance level (p < 0.00014). Furthermore, multivariate logistic regression analysis confirmed that the impact of coffee consumption on obesity differed based on the HECTD4 rs2074356 genotypes. A positive correlation between obesity and coffee consumption was observed, with a more pronounced effect in individuals with the G allele (OR = 1.61 for 1 to <2 cups/day, p = 1.89 × 10^-37; OR = 1.82 for ≥2 cups/day, p = 1.73 × 10^-42) than in those with the A allele (OR = 1.47 for 1 to <2 cups/day, p = 7.41 × 10^-17; OR = 1.45 for ≥2 cups/day, p = 7.24 × 10^-11).

Conclusion: Our findings suggest that the influence of coffee consumption on obesity may vary in Koreans depending on the HECTD4 gene variant.

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HECTD4 基因变异、肥胖与饮用咖啡之间的关系。

背景：在全基因组关联研究中，HECT结构域E3泛素蛋白连接酶4（HECTD4）基因被认为与肥胖相关特征和咖啡消费有关。然而，尚未在韩国人中检测咖啡消费与肥胖之间的基因变异关系。因此，我们研究了 HECTD4 基因变异是否会影响肥胖与咖啡之间的关系：本研究分析了 58,698 名健康体检者中咖啡饮用量与肥胖之间的相关性。参与者被分为肥胖（体重指数≥25.0 kg/m2）和非肥胖（18.5 ≤体重指数2）两类。食物消耗量通过食物频率问卷进行评估：根据 Bonferroni 校正的显著性水平（P -37；OR = 1.82（≥2 杯/天），P = 1.73 × 10-42），我们发现 4 个 HECTD4 基因变异与肥胖相关特质和咖啡饮用量有关，而 A 等位基因（OR = 1.47（1 至 -17）；OR = 1.45（≥2 杯/天），P = 7.24 × 10-11）与之无关：我们的研究结果表明，韩国人饮用咖啡对肥胖的影响可能因 HECTD4 基因变异而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Nutrition 医学-营养学

CiteScore

10.60

自引率

2.10%

发文量

189

审稿时长

3-6 weeks

期刊介绍： The European Journal of Clinical Nutrition (EJCN) is an international, peer-reviewed journal covering all aspects of human and clinical nutrition. The journal welcomes original research, reviews, case reports and brief communications based on clinical, metabolic and epidemiological studies that describe methodologies, mechanisms, associations and benefits of nutritional interventions for clinical disease and health promotion. Topics of interest include but are not limited to: Nutrition and Health (including climate and ecological aspects) Metabolism & Metabolomics Genomics and personalized strategies in nutrition Nutrition during the early life cycle Health issues and nutrition in the elderly Phenotyping in clinical nutrition Nutrition in acute and chronic diseases The double burden of ''malnutrition'': Under-nutrition and Obesity Prevention of Non Communicable Diseases (NCD)