Exploring the impact of polychlorinated biphenyls on comorbidity and potential mitigation strategies.

IF 3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Frontiers in Public Health Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.3389/fpubh.2024.1474994
Ying Gao, Han Lu, Huan Zhou, Jiaxing Tan
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引用次数: 0

Abstract

Introduction: Polychlorinated Biphenyls (PCBs) persist in the environment and accumulate in humans. Currently, there is a lack of understanding about the overall impact of PCBs on human health, and effective interventions for exposed populations are insufficient.

Methods: Our study aimed to assess the impact of PCBs on various diseases and mortality risks using data from the National Health and Nutrition Examination Survey, while proposing lifestyle adjustments, particularly dietary modifications, to mitigate mortality risk. Statistical analyses employed principal component analysis, multifactorial logistic regression, multifactorial Cox regression, comorbidity network analysis, and machine learning prediction models.

Results: Results indicated significant associations between 7 types of PCBs and 12 diseases (p < 0.05), with 6 diseases showing significant positive correlations (OR > 1, p < 0.05), along with listing the 25 most relevant diseases, such as asthma and chronic bronchitis (OR [95% CI] = 5.85 [4.37, 7.83], p < 0.0001), arthritis and osteoporosis (OR [95% CI] = 6.27 [5.23, 7.55], p < 0.0001). This suggested that PCBs may be intimately involved in the development and progression of multiple diseases. By constructing multidimensional machine learning models and conducting multiple iterations for precision and error measurement, PCBs may have the potential to become specific biomarkers for certain diseases in the future. Building upon this, we further suggested that controlling dietary intake to reduce dietary inflammatory index (DII) could lower mortality and disease risks.

Discussion: While PCBs were independent risk factors for mortality, substantial evidence suggested that adjusting DII might mitigate the adverse effects of PCBs to some extent. Further physiological mechanisms require deeper exploration through additional research.

探索多氯联苯对并发症的影响和潜在的缓解策略。
导言:多氯联苯(PCBs)长期存在于环境中,并在人体中累积。目前,人们对多氯联苯对人类健康的总体影响还缺乏了解,针对暴露人群的有效干预措施也不足:我们的研究旨在利用全国健康与营养调查的数据,评估多氯联苯对各种疾病和死亡风险的影响,同时提出调整生活方式,特别是调整饮食的建议,以降低死亡风险。统计分析采用了主成分分析、多因素逻辑回归、多因素 Cox 回归、合并症网络分析和机器学习预测模型:结果表明,7 种多氯联苯与 12 种疾病存在显着关联(P < 0.05),其中 6 种疾病呈现显着正相关(OR > 1,P < 0.05),同时列出了 25 种最相关的疾病,如哮喘和慢性支气管炎(OR [95% CI] = 5.85 [4.37, 7.83],P < 0.0001)、关节炎和骨质疏松症(OR [95% CI] = 6.27 [5.23, 7.55],P < 0.0001)。这表明多氯联苯可能与多种疾病的发生和发展密切相关。通过构建多维机器学习模型并对精确度和误差测量进行多次迭代,多氯联苯未来有可能成为某些疾病的特异性生物标记物。在此基础上,我们进一步提出,控制膳食摄入量以降低膳食炎症指数(DII)可降低死亡率和疾病风险:讨论:虽然多氯联苯是导致死亡的独立风险因素,但大量证据表明,调整 DII 可在一定程度上减轻多氯联苯的不利影响。更多的生理机制需要通过更多的研究来深入探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Public Health
Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health
CiteScore
4.80
自引率
7.70%
发文量
4469
审稿时长
14 weeks
期刊介绍: Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.
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