Repurposing Plant-Based Histone Acetyltransferase Inhibitors: A Review of Novel Therapeutic Strategies Against Drug-Resistant Fungal Biofilms.

IF 2.3 3区 生物学 Q3 MICROBIOLOGY
Tamil Selvam Saravanan, Chaitany Jayprakash Raorane, Vinothkannan Ravichandran, Satish Kumar Rajasekharan
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引用次数: 0

Abstract

The rapid emergence of drug-resistant fungal strains necessitates the development of novel therapeutic approaches for battling biofilm-related infections. Biofilms, efflux pumps, and suppression of virulence traits in pathogenic yeasts are governed by epigenetic enzymes, namely, histone acetyltransferases (HATs) and histone deacetylases (HDACs). The review article is focused on the use of histone acetyltransferase inhibitors (HATi), a mechanism-based epidrug that inactivates the regular function of HATs. With an emphasis on specific plant-based HATi and their Structure-Activity Relationship (SAR), the review enumerates the extensive list of anticancer HATi that can be screened for antifungal activities. By repurposing these anticancer HATi, this approach may help generate broad-spectrum antifungal medications that highlight common biological pathways between fungus and cancer, possibly revolutionizing both treatment domains.

植物组蛋白乙酰转移酶抑制剂的再利用:针对耐药性真菌生物膜的新型治疗策略综述》。
耐药性真菌菌株的迅速出现要求开发新型治疗方法,以应对生物膜相关感染。病原酵母菌的生物膜、外排泵和毒力特征的抑制受表观遗传酶(即组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC))的控制。这篇综述文章的重点是组蛋白乙酰转移酶抑制剂(HATi)的使用,这是一种基于机制的表观药物,能使组蛋白乙酰转移酶的常规功能失活。文章重点介绍了特定的植物组蛋白乙酰转移酶抑制剂及其结构-活性关系(SAR),并列举了大量可用于抗真菌筛选的抗癌组蛋白乙酰转移酶抑制剂。通过重新利用这些抗癌 HATi,这种方法可能有助于产生广谱抗真菌药物,突出真菌和癌症之间共同的生物途径,从而可能彻底改变这两个治疗领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Microbiology
Current Microbiology 生物-微生物学
CiteScore
4.80
自引率
3.80%
发文量
380
审稿时长
2.5 months
期刊介绍: Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment. Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas: physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.
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