Impact of low physical activity on cardiovascular disease across regions and demographic groups: insights from the Global Burden of Disease Study.

IF 4.8 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2025-06-23 DOI:10.1093/ehjqcco/qcae093

Changxing Liu, Zhirui Zhang, Boyu Wang, Tianwei Meng, Chengjia Li, Hongwei Liu, Xulong Zhang, Kai Kang

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引用次数: 0

Abstract

Background: Cardiovascular disease (CVD) is a leading cause of death globally, with low physical activity (LPA) as a significant modifiable risk factor. The prevalence of LPA remains high, necessitating a comprehensive assessment of its impact on CVD.

Methods and results: We applied Joinpoint regression to assess trends in deaths and disability-adjusted life years (DALYs) and employed autoregressive integrated moving average models to project future LPA-related burdens. From 1990 to 2021, CVD-related deaths due to LPA rose from 218 938 to 371 736 globally, with the most significant increases in Southeast Asia and Sub-Saharan Africa. DALYs surged from 4.47 million to 7.29 million. Although age-standardized death rates showed a slight decline in high-income countries (-2.27% EAPC), lower-income regions experienced a steady rise. YLDs grew from 344 680 to 725 181, while YLLs increased from 4.13 million to 6.57 million, with older adults (75+ years) carrying the highest burden.

Conclusion: The growing burden of CVD linked to LPA highlights the urgent need for interventions, particularly in low- and middle-income countries, to reduce future risks and improve public health outcomes.

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不同地区和人口组别中低体力活动对心血管疾病的影响：全球疾病负担研究的启示》。

背景：心血管疾病（CVD）是导致全球死亡的主要原因，而体力活动不足（LPA）是一个重要的可改变风险因素。LPA 的发病率仍然很高，因此有必要对其对心血管疾病的影响进行全面评估：方法：我们采用联结点回归法评估死亡人数和残疾调整生命年（DALYs）的趋势，并采用ARIMA模型预测未来与体重指数相关的负担：从 1990 年到 2021 年，全球因低密度脂蛋白胆固醇引起的心血管疾病相关死亡人数从 218,938 人增加到 371,736 人，其中东南亚和撒哈拉以南非洲的增幅最大。残疾调整寿命年数从 447 万激增至 729 万。虽然高收入国家的年龄标准化死亡率略有下降（-2.27% EAPC），但低收入地区的死亡率却稳步上升。年长死亡率从 344,680 例增加到 725,181 例，而年幼死亡率从 413 万例增加到 657 万例，其中老年人（75 岁以上）的负担最重：与低密度脂蛋白胆固醇有关的心血管疾病负担日益加重，突出表明迫切需要采取干预措施，尤其是在中低收入国家，以降低未来风险并改善公共卫生成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Heart Journal - Quality of Care and Clinical Outcomes CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

9.40

自引率

3.80%

发文量

期刊介绍： European Heart Journal - Quality of Care & Clinical Outcomes is an English language, peer-reviewed journal dedicated to publishing cardiovascular outcomes research. It serves as an official journal of the European Society of Cardiology and maintains a close alliance with the European Heart Health Institute. The journal disseminates original research and topical reviews contributed by health scientists globally, with a focus on the quality of care and its impact on cardiovascular outcomes at the hospital, national, and international levels. It provides a platform for presenting the most outstanding cardiovascular outcomes research to influence cardiovascular public health policy on a global scale. Additionally, the journal aims to motivate young investigators and foster the growth of the outcomes research community.