Representational drift in barrel cortex is receptive field dependent.

IF 8.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Current Biology Pub Date : 2024-12-16 Epub Date: 2024-11-13 DOI:10.1016/j.cub.2024.10.021
Alisha Ahmed, Bettina Voelcker, Simon Peron
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引用次数: 0

Abstract

Cortical populations often exhibit changes in activity even when behavior is stable. How behavioral stability is maintained in the face of such "representational drift" remains unclear. One possibility is that some neurons are more stable than others. We examined whisker touch responses in layers 2-4 of the primary vibrissal somatosensory cortex (vS1) over several weeks in mice stably performing an object detection task with two whiskers. Although the number of touch neurons remained constant, individual neurons changed with time. Touch-responsive neurons with broad receptive fields were more stable than narrowly tuned neurons. Transitions between functional types were non-random: before becoming broadly tuned, unresponsive neurons first passed through a period of narrower tuning. Broadly tuned neurons in layers 2 and 3 with higher pairwise correlations to other touch neurons were more stable than neurons with lower correlations. Thus, a small population of broadly tuned and synchronously active touch neurons exhibits elevated stability and may be particularly important for behavior.

桶状皮层的表象漂移与感受野有关。
即使在行为稳定的情况下,皮层群体的活动也经常会发生变化。面对这种 "表征漂移",行为稳定性是如何维持的,目前仍不清楚。一种可能是某些神经元比其他神经元更稳定。我们研究了用两根胡须稳定执行物体探测任务的小鼠数周内初级振动体感皮层(vS1)2-4层的胡须触觉反应。虽然触觉神经元的数量保持不变,但单个神经元会随着时间的推移而发生变化。具有宽感受野的触觉反应神经元比窄调谐神经元更稳定。功能类型之间的转换是非随机的:在成为宽调谐神经元之前,无反应的神经元首先会经历一段较窄调谐期。第 2 层和第 3 层的宽调谐神经元与其他触觉神经元的成对相关性较高,比相关性较低的神经元更稳定。因此,一小部分广泛调谐且同步活跃的触觉神经元表现出更高的稳定性,可能对行为特别重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Biology
Current Biology 生物-生化与分子生物学
CiteScore
11.80
自引率
2.20%
发文量
869
审稿时长
46 days
期刊介绍: Current Biology is a comprehensive journal that showcases original research in various disciplines of biology. It provides a platform for scientists to disseminate their groundbreaking findings and promotes interdisciplinary communication. The journal publishes articles of general interest, encompassing diverse fields of biology. Moreover, it offers accessible editorial pieces that are specifically designed to enlighten non-specialist readers.
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