The Association Between Obesity, Chronic Inflammation, Metabolic Disorders and Mood Disorders Among Patients up to 12 Months After Hospitalization for SARS-CoV-2.

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Diagnostics Pub Date : 2024-10-23 DOI:10.3390/diagnostics14212357

Kamila Rachubińska, Alicja Mińko, Iwona Rotter, Joanna Sołek-Pastuszka, Przemysław Ustianowski, Karolina Skonieczna-Żydecka, Elżbieta Grochans

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引用次数: 0

Abstract

Background/objectives: The relationship between BMI, inflammation, and mental health is complex. A high BMI, especially obesity, is associated with chronic inflammation, which can lead to mental disorders such as depression. Inflammatory cytokines affect neurotransmitters and the stress axis, worsening mental health. Obesity and mental disorders can mutually reinforce each other. New findings show that inflammation can lead to neurobiological changes, and the gut microbiota may play a key role. Obesity has been implicated as a factor in the high mortality and duration of influenza-like illnesses, even in people who do not have other chronic diseases that may increase the risk of complications. The aim of this study was to determine the associations between BMI and chronic inflammation, metabolic disorders, depression, and anxiety in patients hospitalized with COVID-19 up to 12 months after hospitalization.

Methods: The study included 248 participants previously hospitalized for SARS-CoV-2 infection up to 12 months after hospitalization. The study was conducted in a multistage design using a diagnostic survey, anthropometric measurements, and laboratory methods.

Results: A statistically significantly higher BDI-II score was observed among women. Statistical analysis showed a statistically significant higher GAD-7 score among women and those over 75 years of age.

Conclusions: Higher BMI among subjects is often associated with elevated values of inflammatory markers and immune cells, such as WBC, neutrophils, monocytes, and CRP, as well as higher blood glucose levels. These associations may be related to the chronic inflammation and metabolic disorders that often accompany obesity. Lymphocytes and eosinophils may show more varied relationships depending on individual factors and specific health conditions. It is therefore important to continue research in this area.

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SARS-CoV-2 患者住院 12 个月后肥胖、慢性炎症、代谢紊乱和情绪失调之间的关系。

背景/目的：体重指数、炎症和心理健康之间的关系十分复杂。高体重指数（尤其是肥胖）与慢性炎症有关，而慢性炎症可导致抑郁症等精神疾病。炎症细胞因子会影响神经递质和压力轴，从而恶化心理健康。肥胖和精神障碍可以相互促进。新的研究结果表明，炎症可导致神经生物学变化，而肠道微生物群可能在其中扮演着关键角色。肥胖已被认为是导致流感样疾病死亡率高和持续时间长的一个因素，即使是没有其他可能增加并发症风险的慢性疾病的人也是如此。本研究旨在确定 COVID-19 住院患者在住院 12 个月后的体重指数与慢性炎症、代谢紊乱、抑郁和焦虑之间的关系：研究对象包括 248 名曾因感染 SARS-CoV-2 而住院的患者，研究时间为住院后 12 个月。研究采用多阶段设计，使用诊断调查、人体测量和实验室方法：结果：据统计，女性的 BDI-II 评分明显更高。统计分析显示，女性和 75 岁以上人群的 GAD-7 评分明显更高：结论：受试者的体重指数越高，炎症指标和免疫细胞（如白细胞、中性粒细胞、单核细胞和 CRP）的值往往越高，血糖水平也越高。这些关联可能与肥胖通常伴随的慢性炎症和代谢紊乱有关。淋巴细胞和嗜酸性粒细胞可能会因个体因素和具体健康状况的不同而显示出更多不同的关系。因此，继续开展这方面的研究非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

4.70

自引率

8.30%

发文量

2699

审稿时长

19.64 days

期刊介绍： Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.