Diabetic Peripheral Neuropathy and Glycemia Risk Index in Type 2 Diabetes: A Cross-Sectional Study.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI:10.2147/DMSO.S482824

Yuchen Tang, PingPing Zhang, Li Li, Jialin Li

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Abstract

Purpose: Diabetic peripheral neuropathy (DPN) is a prevalent chronic complication of diabetes which is linked to chronic hyperglycemia and glycemic variability. This study aimed to investigate the association between the glycemia risk index (GRI) and DPN in patients with type 2 diabetes mellitus (T2DM) using continuous glucose monitoring (CGM) data.

Patients and methods: From 2019 to 2023, 862 adults diagnosed with T2DM were enrolled at a tertiary care diabetes center in Ningbo, China. The medical history and laboratory parameters were recorded. Neurophysiological examinations were performed to evaluate DPN. The CGM data were recorded for 14 days, and the GRI was calculated based on these data. Multivariate logistic regression analyses were conducted to assess the odds ratio (OR) for DPN with an increased GRI.

Results: The prevalence of DPN in the ascending GRI quartiles was 41.6%, 47.9%, 49.1%, and 59.5%, respectively (P for trend < 0.001). In the multivariable logistic analysis, the highest GRI quartile exhibited a 63% greater risk of DPN (OR 1.631, 95% CI: 1.071 to 2.484, P = 0.023) than the lowest quartile after adjusted for age, sex, body mass index, diabetes duration, blood pressure, creatinine, urinary albumin-to-creatinine ratio, lipid profile and glycated hemoglobin.

Conclusion: High GRI levels, as measured by CGM, were associated with a greater likelihood of DPN in T2DM patients.

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2 型糖尿病患者的糖尿病周围神经病变和血糖风险指数：一项横断面研究

目的：糖尿病周围神经病变（DPN）是一种常见的糖尿病慢性并发症，与长期高血糖和血糖变化有关。本研究旨在利用连续血糖监测（CGM）数据调查2型糖尿病（T2DM）患者的血糖风险指数（GRI）与DPN之间的关联：从2019年至2023年，中国宁波的一家三级糖尿病中心共招募了862名确诊为T2DM的成年人。记录病史和实验室参数。进行神经电生理检查以评估DPN。记录 14 天的 CGM 数据，并根据这些数据计算 GRI。进行了多变量逻辑回归分析，以评估DPN与GRI增加的几率比（OR）：结果：在 GRI 递增的四分位数中，DPN 患病率分别为 41.6%、47.9%、49.1% 和 59.5%（趋势 P <0.001）。在多变量逻辑分析中，在对年龄、性别、体重指数、糖尿病病程、血压、肌酐、尿白蛋白与肌酐比值、血脂状况和糖化血红蛋白进行调整后，GRI最高的四分位数比最低的四分位数患DPN的风险高63%（OR 1.631，95% CI：1.071至2.484，P = 0.023）：结论：通过 CGM 测量的高 GRI 水平与 T2DM 患者发生 DPN 的可能性较大相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.