Clinical Value of Urinary Wilms' Tumour-1 and Mu-Glutathione S-Transferase Gene Expression in Kidney Injury in Type 2 Diabetes Mellitus.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI:10.2147/DMSO.S483457

Feng Cai, Li-Li Xu, Xin Tang, Lin-Lin Wang

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Abstract

Objective: To investigate the diagnostic value of urinary Wilms' tumour-1 (WT-1) and mu-glutathione S-transferase (Mu-GST) gene expression for detecting kidney injury in type 2 diabetes mellitus (T2DM).

Methods: Patients treated between October 2022 and June 2023 were divided into two groups: a diabetic nephropathy (DN) group (105 patients) and a diabetes mellitus (DM) group (100 patients). Additionally, 100 healthy individuals undergoing routine medical check-ups were selected as the control group. The urinary albumin/creatinine ratio (ACR), as well as urinary WT-1 and Mu-GST expression levels, were measured. The sensitivity and specificity of these markers for predicting renal injury were evaluated.

Results: The levels of ACR, WT-1 and Mu-GST in the DN group were significantly higher than those in the DM and control groups. The ACR in the DM group was also significantly higher than that in the control group (P < 0.05), and WT-1 and Mu-GST gene expression levels demonstrated a positive correlation with ACR (r = 0.391 and 0.342, respectively). The sensitivity and specificity of WT-1 were 74% and 95%, respectively, whereas those of Mu-GST were 70% and 96%, respectively. The combined detection of WT-1 and Mu-GST yielded a sensitivity of 82% and a specificity of 97%.

Conclusion: The levels of WT-1 and Mu-GST gene expression are closely related to T2DM kidney injury, helping to identify the location of kidney injury to some extent, which provides valuable information for the clinical diagnosis and treatment of kidney injury.

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尿液中 Wilms' Tumour-1 和 Mu-Glutathione S-Transferase 基因表达在 2 型糖尿病肾损伤中的临床价值。

目的研究尿液中Wilms' tumour-1（WT-1）和μ-谷胱甘肽S-转移酶（Mu-GST）基因表达对检测2型糖尿病（T2DM）肾损伤的诊断价值：将2022年10月至2023年6月期间接受治疗的患者分为两组：糖尿病肾病（DN）组（105名患者）和糖尿病（DM）组（100名患者）。此外，还挑选了 100 名接受常规体检的健康人作为对照组。测量了尿白蛋白/肌酐比值（ACR）以及尿 WT-1 和 Mu-GST 表达水平。评估了这些指标预测肾损伤的敏感性和特异性：结果：DN组的ACR、WT-1和Mu-GST水平明显高于DM组和对照组。DM 组的 ACR 也明显高于对照组（P < 0.05），WT-1 和 Mu-GST 基因表达水平与 ACR 呈正相关（r = 0.391 和 0.342）。WT-1 的敏感性和特异性分别为 74% 和 95%，而 Mu-GST 的敏感性和特异性分别为 70% 和 96%。联合检测 WT-1 和 Mu-GST 的灵敏度为 82%，特异性为 97%：结论：WT-1和Mu-GST基因表达水平与T2DM肾损伤密切相关，在一定程度上有助于确定肾损伤的部位，为肾损伤的临床诊断和治疗提供了有价值的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.