Cardiac involvement in a female patient with Beçhet's disease: newer diagnostic and therapeutic approaches-a case report.

IF 0.8 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
European Heart Journal: Case Reports Pub Date : 2024-10-18 eCollection Date: 2024-11-01 DOI:10.1093/ehjcr/ytae544
Maria Kouremeti, Athanasios Kordalis, Yannis Dimitroglou, Konstantinos Tsioufis, Constantina Aggeli
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引用次数: 0

Abstract

Background: Behçet's disease (BD) is a multisystemic chronic inflammatory disorder. Cardiac manifestations in BD are extremely rare. There have been no reports of cardiac involvement of BD and especially endomyocardial fibrosis in the left ventricle (LV).

Case summary: A 50-year-old woman presented at the emergency department experiencing palpitations and fatigue, accompanied by elevated levels of B-type natriuretic peptide. Her medical history included mucocutaneous involvement of BD. Vital signs were within normal ranges, and electrocardiography showed a normal sinus rhythm. Physical examination did not reveal any pathological findings. The 24 h ambulatory electrocardiogram monitoring indicated sinus rhythm with premature ventricular contractions. Transthoracic echocardiography demonstrated a reduced LV ejection fraction. Further investigation with cardiac magnetic resonance imaging reported diffused areas of subendocardial enhancement, indicative of fibrosis likely due to vasculitis probably associated with BD. The patient was administered tartrate metoprolol, eplerenone, and dapagliflozin in addition to the ongoing medical treatment for BD, which included methylprednisolone, colchicine, and apremilast. This treatment approach resulted in an improvement in the patient's clinical condition.

Discussion: This case highlights that diffuse subendocardial fibrosis of the LV may be associated with the underlying BD.

贝切特氏病女性患者的心脏受累:新的诊断和治疗方法--病例报告。
背景:白塞氏病(BD)是一种多系统慢性炎症性疾病。BD的心脏表现极为罕见。病例摘要:一名 50 岁女性因心悸、乏力、B 型钠尿肽水平升高到急诊科就诊。她的病史包括 BD 粘膜受累。生命体征在正常范围内,心电图显示窦性心律正常。体格检查未发现任何病理结果。24 小时动态心电图监测显示为窦性心律,伴有室性早搏。经胸超声心动图显示左心室射血分数降低。心脏磁共振成像的进一步检查报告显示心内膜下弥漫性强化区域,表明可能是与 BD 相关的血管炎引起的纤维化。除了正在进行的 BD 内科治疗(包括甲基强的松龙、秋水仙碱和阿普司特)外,该患者还接受了酒石酸美托洛尔、依普利酮和达帕格列非嗪的治疗。这种治疗方法改善了患者的临床状况:本病例强调了左心室弥漫性心内膜下纤维化可能与潜在的 BD 有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Heart Journal: Case Reports
European Heart Journal: Case Reports Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.30
自引率
10.00%
发文量
451
审稿时长
14 weeks
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