Effects of parental socioeconomic status on offspring's fetal neurodevelopment.

IF 2.9 2区医学 Q2 NEUROSCIENCES

Cerebral cortex Pub Date : 2024-11-05 DOI:10.1093/cercor/bhae443

Julia Mathan, Mélanie Maximino-Pinheiro, Qin He, Gabriela Rezende, Iris Menu, Cloelia Tissier, Emilie Salvia, Katell Mevel, Lorna Le Stanc, Julie Vidal, Marine Moyon, Lisa Delalande, Francois Orliac, Nicolas Poirel, Catherine Oppenheim, Olivier Houdé, Boris Chaumette, Grégoire Borst, Arnaud Cachia

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引用次数: 0

Abstract

Emerging evidence underscores the prenatal period's critical role in shaping later cognition and health, influenced by an intricate interplay of parental genetic and environmental factors. Birth weight is commonly used as a retrospective indicator of fetal development, but recent focus has shifted to more specific proxies of neurodevelopment, like cortical sulcal patterns, which are established in utero and remain stable after birth. This study aimed to elucidate the interrelated effects of parental socioeconomic status, brain volume, birth weight, and sulcal patterns in the anterior cingulate cortex. Utilizing structural Magnetic Resonance Imaging (MRI), parental educational attainment, and related polygenic risk scores, the study analyzed 203 healthy right-handed participants aged 9 to 18. Structural equation modeling demonstrated that the anterior cingulate cortex sulcal pattern is influenced by parental socioeconomic status and global brain volume, with socioeconomic status correlating with a polygenic risk score. These findings suggest that prenatal neurodevelopmental processes may mediate the intergenerational transmission of inequalities.

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父母的社会经济地位对后代胎儿神经发育的影响。

新出现的证据强调了产前时期在塑造日后认知和健康方面的关键作用，而这一作用受到父母遗传和环境因素错综复杂的相互作用的影响。出生体重通常被用作胎儿发育的回顾性指标，但最近的研究重点已转移到更具体的神经发育代用指标上，如皮层沟纹模式，这种模式在子宫内就已建立，并在出生后保持稳定。本研究旨在阐明父母的社会经济地位、脑容量、出生体重和前扣带皮层沟纹的相互影响。该研究利用结构磁共振成像（MRI）、父母教育程度和相关的多基因风险评分，对203名9至18岁的健康右撇子参与者进行了分析。结构方程模型显示，前扣带回皮层沟纹模式受父母社会经济地位和整体脑容量的影响，社会经济地位与多基因风险评分相关。这些研究结果表明，产前神经发育过程可能是不平等代际传递的中介。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.