Association between life's essential 8 and cognitive impairment in older patients: results from NHANES 2011-2014.

IF 3.4 2区医学 Q2 GERIATRICS & GERONTOLOGY

BMC Geriatrics Pub Date : 2024-11-14 DOI:10.1186/s12877-024-05547-4

Hui Wang, Sensen Wu, Dikang Pan, Yachan Ning, Cong Wang, Jianming Guo, Yongquan Gu

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引用次数: 0

Abstract

Background: This study aimed to examine the association between the American Heart Association's (AHA) newly revised Life's Essential 8 (LE8) algorithm, designed for assessing cardiovascular health (CVH), and cognitive impairment among older adults in the United States.

Methods: This study employed a cross-sectional design, utilizing data from the 2011-2014 National Health and Nutrition Examination Survey to explore the relationship between CVH and cognitive impairment in older adults. CVH scores are assessed based on the AHA definition of the LE8, categorized into three tiers: low (0-49), medium (50-79), and high (80-100). Cognitive impairment is evaluated using three distinct scoring systems: the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST). The lowest quartile as the cut-off point; below or equal to the lower quartile was considered as low cognitive population, and above the lower quartile was normal population. To analyze the association, multivariable logistic regression and restricted cubic spline (RCS) models were employed.

Results: A significant negative correlation exists between the LE8 and cognitive impairment. After adjusting for multiple variables, the odds ratios (OR) for cognitive impairment, as measured by the CERAD, AFT, and DSST, were compared between patients with high and low CVH. The results indicated OR values of 0.60 (95% CI: 0.36-0.98), 0.72 (95% CI: 0.52-0.97), and 0.29 (95% CI: 0.16-0.53) for the CERAD, AFT, and DSST, respectively. Additionally, the RCS curve demonstrated a significant linear relationship between lifestyle factors encapsulated by the LE8 and cognitive impairment.

Conclusions: The findings indicate higher adherence to LE8 was associated with lower odds of cognitive impairment. Furthermore, maintaining optimal CVH is crucial in preventing cognitive impairment.

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生活必需品 8 与老年患者认知障碍之间的关系：2011-2014 年美国国家健康调查（NHANES）结果。

研究背景本研究旨在探讨美国心脏协会（AHA）新修订的用于评估心血管健康（CVH）的 "生命必备 8 要素"（LE8）算法与美国老年人认知障碍之间的关系：本研究采用横断面设计，利用 2011-2014 年全国健康与营养调查的数据来探讨老年人心血管健康与认知障碍之间的关系。CVH评分根据美国心脏协会对LE8的定义进行评估，分为三个等级：低（0-49）、中（50-79）和高（80-100）。认知障碍采用三种不同的评分系统进行评估：建立阿尔茨海默病登记联盟（CERAD）、动物流畅性测试（AFT）和数字符号替换测试（DSST）。以最低四分位数为分界点，低于或等于最低四分位数为低认知人群，高于最低四分位数为正常人群。为了分析两者之间的关联，采用了多变量逻辑回归和限制性立方样条（RCS）模型：结果：LE8与认知障碍之间存在明显的负相关。在对多个变量进行调整后，比较了高 CVH 患者和低 CVH 患者的认知功能障碍几率比（OR），CERAD、AFT 和 DSST 均对认知功能障碍进行了测量。结果显示，CERAD、AFT 和 DSST 的 OR 值分别为 0.60（95% CI：0.36-0.98）、0.72（95% CI：0.52-0.97）和 0.29（95% CI：0.16-0.53）。此外，RCS 曲线显示，LE8 所包含的生活方式因素与认知障碍之间存在显著的线性关系：结论：研究结果表明，较高的 LE8 坚持率与较低的认知障碍几率相关。此外，保持最佳的 CVH 对预防认知障碍至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Geriatrics GERIATRICS & GERONTOLOGY-

CiteScore

5.70

自引率

7.30%

发文量

873

审稿时长

20 weeks

期刊介绍： BMC Geriatrics is an open access journal publishing original peer-reviewed research articles in all aspects of the health and healthcare of older people, including the effects of healthcare systems and policies. The journal also welcomes research focused on the aging process, including cellular, genetic, and physiological processes and cognitive modifications.