Meta-analysis reveals an inverse relationship between Alzheimer’s disease and cancer

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2024-11-08 DOI:10.1016/j.bbr.2024.115327

Gui Zheng , Mengli Xu , Zehua Dong , Zeinab Abdelrahman , Xiaosheng Wang

引用次数: 0

Abstract

Recent reports have suggested an inverse relationship between Alzheimer's disease (AD) and cancer, although the underlying mechanism remains unclear. We performed an epidemiological meta-analysis to assess cancer likelihood in AD patients and vice versa and explored the role of APOE in tumor immunity across 33 The Cancer Genome Atlas (TCGA) cancer types. Our analysis revealed that people with AD are epidemiologically less likely to develop cancer than individuals without AD (RR: 0.53), and cancer patients are less likely to develop AD than non-cancer patients (RR: 0.61). Notably, APOE expression was positively associated with anti-tumor immune signatures and prevalent in early-stage tumors. This research reveals that AD patients are less likely to develop cancer and vice versa, pinpoints APOE gene as a risk factor for AD with anti-tumor activity, and provides new insight into the epidemiologically observed inverse relationship between both diseases.

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元分析揭示了阿尔茨海默病与癌症之间的反比关系。

最近的报告表明，阿尔茨海默病（AD）与癌症之间存在反向关系，但其潜在机制仍不清楚。我们进行了一项流行病学荟萃分析，以评估阿尔茨海默病患者罹患癌症的可能性，反之亦然，并探讨了 33 种癌症基因组图谱（TCGA）中 APOE 在肿瘤免疫中的作用。我们的分析表明，从流行病学角度看，注意力缺失症患者患癌症的几率低于非注意力缺失症患者（RR：0.53），癌症患者患注意力缺失症的几率低于非癌症患者（RR：0.61）。值得注意的是，APOE的表达与抗肿瘤免疫特征呈正相关，并在早期肿瘤中流行。这项研究揭示了注意力缺失症患者罹患癌症的几率较低，反之亦然，指出 APOE 基因是具有抗肿瘤活性的注意力缺失症风险因素，并为流行病学观察到的这两种疾病之间的反比关系提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.