Biodegradable stimulating electrodes for resident neural stem cell activation in vivo

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2024-11-09 DOI:10.1016/j.biomaterials.2024.122957

Tianhao Chen , Kylie Sin Ki Lau , Aryan Singh , Yi Xin Zhang , Sara Mohseni Taromsari , Meysam Salari , Hani E. Naguib , Cindi M. Morshead

{"title":"Biodegradable stimulating electrodes for resident neural stem cell activation in vivo","authors":"Tianhao Chen , Kylie Sin Ki Lau , Aryan Singh , Yi Xin Zhang , Sara Mohseni Taromsari , Meysam Salari , Hani E. Naguib , Cindi M. Morshead","doi":"10.1016/j.biomaterials.2024.122957","DOIUrl":null,"url":null,"abstract":"<div><div>Brain stimulation has been recognized as a clinically effective strategy for treating neurological disorders. Endogenous brain neural precursor cells (NPCs) have been shown to be electrosensitive cells that respond to electrical stimulation by expanding in number, undergoing directed cathodal migration, and differentiating into neural phenotypes <em>in vivo</em>, supporting the application of electrical stimulation to promote neural repair. In this study, we present the design of a flexible and biodegradable brain stimulation electrode for temporally regulated neuromodulation of NPCs. Leveraging the cathodally skewed electrochemical window of molybdenum and the volumetric charge transfer properties of conductive polymer, we engineered the electrodes with high charge injection capacity for the delivery of biphasic monopolar stimulation. We demonstrate that the electrodes are biocompatible and can deliver an electric field sufficient for NPC activation for 7 days post implantation before undergoing resorption in physiological conditions, thereby eliminating the need for surgical extraction. The biodegradable electrode demonstrated its potential to be used for NPC-based neural repair strategies.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122957"},"PeriodicalIF":12.8000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0142961224004927","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Brain stimulation has been recognized as a clinically effective strategy for treating neurological disorders. Endogenous brain neural precursor cells (NPCs) have been shown to be electrosensitive cells that respond to electrical stimulation by expanding in number, undergoing directed cathodal migration, and differentiating into neural phenotypes in vivo, supporting the application of electrical stimulation to promote neural repair. In this study, we present the design of a flexible and biodegradable brain stimulation electrode for temporally regulated neuromodulation of NPCs. Leveraging the cathodally skewed electrochemical window of molybdenum and the volumetric charge transfer properties of conductive polymer, we engineered the electrodes with high charge injection capacity for the delivery of biphasic monopolar stimulation. We demonstrate that the electrodes are biocompatible and can deliver an electric field sufficient for NPC activation for 7 days post implantation before undergoing resorption in physiological conditions, thereby eliminating the need for surgical extraction. The biodegradable electrode demonstrated its potential to be used for NPC-based neural repair strategies.

Abstract Image

查看原文本刊更多论文

用于激活体内驻留神经干细胞的可生物降解刺激电极。

脑刺激被认为是治疗神经系统疾病的一种临床有效策略。研究表明，内源性脑神经前体细胞（NPCs）是对电刺激敏感的细胞，它们对电刺激的反应是数量增加、定向阴极迁移以及在体内分化成神经表型，这为应用电刺激促进神经修复提供了支持。在这项研究中，我们设计了一种灵活、可生物降解的脑刺激电极，用于对 NPCs 进行时间调控的神经调节。利用钼的阴极偏斜电化学窗口和导电聚合物的体积电荷转移特性，我们设计了具有高电荷注入能力的电极，用于提供双相单极刺激。我们证明了电极的生物相容性，并能在植入后 7 天内提供足以激活鼻咽癌的电场，然后才会在生理条件下发生吸收，因此无需手术取出。这种可生物降解电极证明了其用于基于鼻咽癌的神经修复策略的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.