Utilization of Tin(IV) Complex of N-confused Porphyrin for Antiproliferative Activity and Antimicrobial Photodynamic Chemotherapy.

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2024-11-13 DOI:10.1002/asia.202401027

Rajesh Kumar, Pankaj Kumar Chaudhary, Ramasare Prasad, Muniappan Sankar

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引用次数: 0

Abstract

Sn(IV) complex of N-Confused Porphyrin (Sn(IV)-NCP) has been prepared and characterized by several spectroscopic techniques to verify its structure and purity. Sn(IV)-NCP shows a red shift in both the Soret and Q bands compared to the free base NCTPP. The last Q band appears in the NIR region. Based on these characteristics, we investigated the antiproliferative properties and antimicrobial photodynamic therapy (a-PDT) efficiency of Sn(IV)-NCP against the bacteria Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Further, we investigated the photodynamic activity of Sn (IV)-NCP against Michigan cancer foundation-7 (MCF-7) cancer cells, to assess its potential as an effective therapeutic agent. Treated MCF-7 cells with the compound show cytotoxic effects as compared to the untreated ones. At a higher concentration (128 µg/ml), Sn(IV)-NCP exhibited 90% inhibition, while at a lower concentration (32 µg/ml), it showed 70% inhibition in MCF-7 cells. The IC50 value for this compound against MCF-7 cells was found 16.67 µg/ml. At 32 µg/ml, Sn(IV)-NCP showed only around 4% cell inhibition, indicating minimal cytotoxic effects on human embryonic kidney cells (HEK293).

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利用 N-混淆卟啉的锡（IV）络合物进行抗增殖活性和抗菌光动力化疗。

我们制备了 N-融合卟啉的 Sn(IV) 复合物（Sn(IV)-NCP），并采用多种光谱技术对其进行了表征，以验证其结构和纯度。与游离基 NCTPP 相比，Sn(IV)-NCP 的索雷特波段和 Q 波段都发生了红移。最后一个 Q 波段出现在近红外区域。基于这些特性，我们研究了 Sn(IV)-NCP 对大肠杆菌和金黄色葡萄球菌的抗增殖特性和抗菌光动力疗法（a-PDT）效率。此外，我们还研究了 Sn (IV)-NCP 对密歇根癌症基金会-7（MCF-7）癌细胞的光动力活性，以评估其作为有效治疗剂的潜力。与未经处理的细胞相比，用该化合物处理的 MCF-7 细胞显示出细胞毒性效应。在较高浓度（128 微克/毫升）下，Sn(IV)-NCP 对 MCF-7 细胞的抑制率为 90%，而在较低浓度（32 微克/毫升）下，抑制率为 70%。该化合物对 MCF-7 细胞的 IC50 值为 16.67 µg/ml。在 32 微克/毫升的浓度下，Sn(IV)-NCP 对细胞的抑制率仅为 4%左右，这表明它对人类胚胎肾细胞（HEK293）的细胞毒性作用极小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).