Engineering considerations in the design of tissue specific bioink for 3D bioprinting applications.

IF 5.8 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Shivi Tripathi, Madhusmita Dash, Ruchira Chakraborty, Harri Junaedi Lukman, Prasoon Kumar, Shabir Hassan, Hassan Mehboob, Harpreet Singh, Himansu Sekhar Nanda
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Abstract

Over eight million surgical procedures are conducted annually in the United Stats to address organ failure or tissue losses. In response to this pressing need, recent medical advancements have significantly improved patient outcomes, primarily through innovative reconstructive surgeries utilizing tissue grafting techniques. Despite tremendous efforts, repairing damaged tissues remains a major clinical challenge for bioengineers and clinicians. 3D bioprinting is an additive manufacturing technique that holds significant promise for creating intricately detailed constructs of tissues, thereby bridging the gap between engineered and actual tissue constructs. In contrast to non-biological printing, 3D bioprinting introduces added intricacies, including considerations for material selection, cell types, growth, and differentiation factors. However, technical challenges arise, particularly concerning the delicate nature of living cells in bioink for tissue construction and limited knowledge about the cell fate processes in such a complex biomechanical environment. A bioink must have appropriate viscoelastic and rheological properties to mimic the native tissue microenvironment and attain desired biomechanical properties. Hence, the properties of bioink play a vital role in the success of 3D bioprinted substitutes. This review comprehensively delves into the scientific aspects of tissue-centric or tissue-specific bioinks and sheds light on the current challenges of the translation of bioinks and bioprinting.

三维生物打印应用中组织特异性生物墨水设计的工程考虑因素。
在美国,每年有 800 多万例外科手术是为了解决器官衰竭或组织缺失问题。为了满足这一迫切需求,最近的医学进步显著改善了患者的治疗效果,主要是通过利用组织移植技术进行创新性重建手术。尽管付出了巨大努力,修复受损组织仍然是生物工程师和临床医生面临的一大临床挑战。三维生物打印是一种增材制造技术,有望制造出复杂精细的组织结构,从而缩小工程组织和实际组织结构之间的差距。与非生物打印相比,三维生物打印引入了更多复杂因素,包括材料选择、细胞类型、生长和分化因子等方面的考虑。然而,技术上的挑战也随之而来,特别是生物墨水中用于组织构建的活细胞的微妙性质,以及在如此复杂的生物力学环境中对细胞命运过程的有限了解。生物墨水必须具有适当的粘弹性和流变学特性,以模拟原生组织的微环境并获得理想的生物力学特性。因此,生物墨水的特性对三维生物打印替代品的成功起着至关重要的作用。本综述全面探讨了以组织为中心或组织特异性生物墨水的科学方面,并揭示了当前生物墨水和生物打印转化所面临的挑战。
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来源期刊
Biomaterials Science
Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.50%
发文量
556
期刊介绍: Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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