Self-Healing, Electrically Conductive, Antibacterial, and Adhesive Eutectogel Containing Polymerizable Deep Eutectic Solvent for Human Motion Sensing and Wound Healing.

IF 5.5 2区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-14 DOI:10.1021/acs.biomac.4c00960
Shaghayegh Vakili, Zahra Mohamadnia, Ebrahim Ahmadi
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引用次数: 0

Abstract

Flexible electronic devices such as wearable sensors are essential to advance human-machine interactions. Conductive eutectogels are promising for wearable sensors, despite their challenges in self-healing and adhesion properties. This study introduces a multifunctional eutectogel based on a novel polymerizable deep eutectic solvent (PDES) prepared by the incorporation of diallyldimethylammonium chloride (DADMAC) and glycerol in the presence of polycyclodextrin (PCD)/dopamine-grafted gelatin (Gel-DOP)/oxidized sodium alginate (OSA). The synthesized eutectogel has reversible Schiff-base bonds, hydrogen bonds, and host-guest interactions, which enable rapid self-healing upon network disruption. GPDO-15 eutectogel has significant tissue adhesion, high stretchability (419%), good ionic conductivity (0.79 mS·cm-1), and favorable antibacterial and self-healing properties. These eutectogels achieve 90% antibacterial effect, show excellent biocompatibility, and can be used as sensors to monitor human activities with strong stability and durability. The in vivo studies indicate that the eutectogels can improve the wound healing process which makes them an effective option for biological dressings.

自愈性、导电性、抗菌性和粘性共晶凝胶,含有可聚合的深共晶溶剂,用于人体运动传感和伤口愈合。
可穿戴传感器等柔性电子设备对于促进人机交互至关重要。尽管导电共晶凝胶在自愈合和粘附性能方面存在挑战,但它在可穿戴传感器领域大有可为。本研究介绍了一种基于新型可聚合深共晶溶剂(PDES)的多功能共晶凝胶,其制备方法是在聚环糊精(PCD)/多巴胺接枝明胶(Gel-DOP)/氧化海藻酸钠(OSA)存在下,加入二烯丙基二甲基氯化铵(DADMAC)和甘油。合成的共晶凝胶具有可逆的希夫碱键、氢键和主客体相互作用,可在网络中断时快速自我修复。GPDO-15 共晶凝胶具有显著的组织粘附性、高伸展性(419%)、良好的离子导电性(0.79 mS-cm-1)以及良好的抗菌和自愈合特性。这些共晶凝胶的抗菌效果达到了 90%,具有良好的生物相容性,可用作监测人体活动的传感器,具有很强的稳定性和耐久性。体内研究表明,共晶凝胶能改善伤口愈合过程,因此是生物敷料的有效选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomacromolecules
Biomacromolecules 化学-高分子科学
CiteScore
10.60
自引率
4.80%
发文量
417
审稿时长
1.6 months
期刊介绍: Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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