A Prospective, Randomized, Controlled Trial of Methylene Blue Injection for Costal Cartilage Harvest Postoperative Analgesia.

IF 3 2区医学 Q1 SURGERY

Aesthetic Surgery Journal Pub Date : 2024-11-12 DOI:10.1093/asj/sjae203

Ziang Zhang, Ziyu Zhu, Hengxin Liu, Jie Chen, Changxin Jin, Xi Zhang

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引用次数: 0

Abstract

Background: In plastic surgery, costal cartilage is an excellent support material. However, postoperative pain from costal cartilage harvesting can impact patient recovery and satisfaction with the surgery. Recent reports have shown that methylene blue (MB) is an effective local analgesic in postoperative management.

Objectives: We aimed to evaluate the safety and effectiveness of MB for pain relief in patients undergoing costal cartilage harvesting.

Methods: A total of 106 patients undergoing costal cartilage harvesting surgery were selected from the plastic surgery department between December 2022 and March 2024. They were randomly divided into 2 groups: the MB group and the ropivacaine group, with 53 patients in each group. Pain levels were assessed with a numerical rating scale, the Insomnia Severity Index (ISI), arm elevation angle, and postoperative satisfaction scales at 1 day, 3 days, 5 days, 1 week, 1 month, and 3 months postoperatively.

Results: Patients receiving MB exhibited a significant decrease in pain scores from 5 days to 1 month of treatment compared to the ropivacaine group. Additionally, in the MB group there was an improvement in ISI scores from 5 days to 1 month compared to the ropivacaine group. Furthermore, during the 3-month follow-up, the MB group had significant increases in satisfaction scores compared to the control group. Arm elevation angle in the MB group was significantly higher compared to the ropivacaine group at 5 days, 1week, and 1month. No serious adverse events were reported, with only 2 patients experiencing an allergic rash.

Conclusions: Methylene blue demonstrated significant pain reduction with minimal adverse effects.

Level of evidence: 3 (therapeutic):

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亚甲蓝注射用于肋软骨切除术后镇痛的前瞻性随机对照试验。

背景介绍在整形外科中，肋软骨是一种极佳的支撑材料。然而，采集肋软骨时产生的术后疼痛会影响患者的恢复和对手术的满意度。最近的报告显示，亚甲蓝（MB）是一种有效的术后局部镇痛剂：我们旨在评估亚甲蓝对肋软骨采集术患者止痛的安全性和有效性：方法：2022年12月至2024年3月期间，整形外科共选取了106名接受肋软骨采集手术的患者。他们被随机分为两组：MB 组和罗哌卡因组，每组 53 人。在术后1天、3天、5天、1周、1个月和3个月，用数字评分量表、失眠严重程度指数（ISI）、手臂抬高角度和术后满意度量表评估疼痛程度：与罗哌卡因组相比，接受 MB 治疗的患者在治疗 5 天至 1 个月期间的疼痛评分明显下降。此外，与罗哌卡因组相比，甲基溴组的 ISI 评分从 5 天到 1 个月都有所提高。此外，在 3 个月的随访中，与对照组相比，甲基溴组的满意度评分显著提高。与罗哌卡因组相比，MB 组的手臂抬高角度在 5 天、1 周和 1 个月时都明显增加。无严重不良事件报告，仅有两名患者出现过敏性皮疹：亚甲蓝可明显减轻疼痛，且不良反应极小：证据等级：3（治疗）：

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aesthetic Surgery Journal SURGERY-

CiteScore

6.20

自引率

20.70%

发文量

309

审稿时长

6-12 weeks

期刊介绍： Aesthetic Surgery Journal is a peer-reviewed international journal focusing on scientific developments and clinical techniques in aesthetic surgery. The official publication of The Aesthetic Society, ASJ is also the official English-language journal of many major international societies of plastic, aesthetic and reconstructive surgery representing South America, Central America, Europe, Asia, and the Middle East. It is also the official journal of the British Association of Aesthetic Plastic Surgeons, the Canadian Society for Aesthetic Plastic Surgery and The Rhinoplasty Society.