Sex Differences in a Real-World Registry Examining Coronary Lithotripsy for Calcified Lesions

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Martijn J.H. van Oort MSc , Federico Oliveri MD , Al Amri Ibtihal MD, PhD , Brian O. Bingen MD, PhD , Bimmer E.P.M. Claessen MD, PhD , Aukelien C. Dimitriu-Leen MD, PhD , Tessel N. Vossenberg MD , Joelle Kefer MD, PhD , Hany Girgis MD , Franka van der Kley MD, PhD , J. Wouter Jukema MD, PhD , Jose M. Montero-Cabezas MD, PhD
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引用次数: 0

Abstract

Intravascular lithotripsy (IVL) has been established as a safe and effective treatment for coronary artery calcification (CAC). This study aimed to evaluate sex-related differences in the treatment with IVL in a real-world, all-comers international registry. Patients who underwent IVL between May 2019 and February 2024 were enrolled from the BENELUX-IVL registry. Patients were divided into men and women groups. Efficacy end points included device success (delivery of the IVL balloon across the target lesion and administration of therapy without related complications), technical success (thrombolysis in myocardial infarction 3 flow and residual stenosis <30% by quantitative coronary analysis and/or fluoroscopically) and procedural success (composite of technical success with absence of in-hospital major adverse cardiovascular events (MACE: cardiac death, myocardial infarction or target vessel revascularization). Safety end points were IVL-related complications and MACE at 1-year follow-up. 454 patients (73 ± 9.0 years) were treated with IVL, comprising 342 men (75%) and 112 women (25%). More women presented with acute coronary syndrome (41% in men vs 54% in women; p = 0.014) and aorto-ostial lesions (17% in men vs 29% in women; p = 0.009), whereas the SYNTAX score (23.5 ± 14.2 in men vs 17.1 ± 1.0 in women; p <0.001) was higher in men. Rates of device success (97% vs 98%; p = 1.000), technical success (90% vs 91%; p = 0.821) procedural success (90% vs 88%; p = 0.749), IVL-related complications (1% vs 2%; p = 0.362) and 1-year MACE rates (12% vs 17%; p = 0.456) were comparable. In conclusion, despite differences in clinical presentation and lesion types, IVL seems to be safe and effective for both sexes across various clinical and anatomical scenarios.
真实世界中冠状动脉碎石术治疗钙化病变登记中的性别差异。
血管内碎石术(IVL)是一种安全有效的冠状动脉钙化(CAC)治疗方法。本研究旨在通过一项真实世界的国际注册研究,评估IVL治疗中与性别相关的差异。BENELUX-IVL登记处招募了2019年5月至2024年2月期间接受IVL治疗的患者。患者分为男性组和女性组。疗效终点包括设备成功率(IVL-球囊在靶病变部位的输送和治疗的实施,无相关并发症)、技术成功率(TIMI 3血流和残余狭窄
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来源期刊
American Journal of Cardiology
American Journal of Cardiology 医学-心血管系统
CiteScore
4.00
自引率
3.60%
发文量
698
审稿时长
33 days
期刊介绍: Published 24 times a year, The American Journal of Cardiology® is an independent journal designed for cardiovascular disease specialists and internists with a subspecialty in cardiology throughout the world. AJC is an independent, scientific, peer-reviewed journal of original articles that focus on the practical, clinical approach to the diagnosis and treatment of cardiovascular disease. AJC has one of the fastest acceptance to publication times in Cardiology. Features report on systemic hypertension, methodology, drugs, pacing, arrhythmia, preventive cardiology, congestive heart failure, valvular heart disease, congenital heart disease, and cardiomyopathy. Also included are editorials, readers'' comments, and symposia.
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