Genetic insights into litter size in goats: A meta-analysis of KISS1 and BMP15 SNP variants

IF 2.2 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Reproduction Science Pub Date : 2024-11-06 DOI:10.1016/j.anireprosci.2024.107632

Mohsen Gholizadeh, Mehre Mohammadnezhad

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引用次数: 0

Abstract

Litter size is a key trait in livestock breeding. The BMP15 and KISS1 genes have been studied in goats, but results on their association with litter size are inconsistent. The objective of this study was to employ a meta-analysis approach to investigate the genetic relationship between the BMP15 (g.735 G>A) and KISS1 (g.2540 C>T and g.2510 G>A) genes and litter size in goats. A total of five studies (including 12 breeds) were included for the g.735 G>A mutation, three studies (including nine breeds) for g.2540 C>T, and two studies (including six breeds) for g.2510 G>A in this meta-analysis. The meta-analysis was conducted under four different genetic models: recessive (GG + AG vs. AA), dominant (GG vs. AG + AA), additive (GG vs. AA) and codominant (GG + AA vs. AG) models of inheritance. Data were analyzed under either random or fixed effects models based on the estimates of I² estimates. A sensitivity analysis was performed by removing one study at a time to determine the stability of the overall results. Funnel plots and the Egger regression tests were also used to assess the publication bias among studies. Significant associations (P< 0.05) were observed between the g.2540 C>T and g.2510 G>A loci and litter size in goats under the additive (SMD = −0.469, 95 % CI = −0.908 to −0.030, P-value = 0.036) and codominant (SMD = 0.147, 95 % CI = 0.003–0.291, P = 0.046) genetic models, respectively. Our results did not identify any significant association between g.735 G>A of BMP15 and litter size under the investigated genetic models.

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山羊产仔数的遗传学研究：KISS1和BMP15 SNP变异的荟萃分析。

产仔数是家畜育种中的一个关键性状。已经对山羊的 BMP15 和 KISS1 基因进行了研究，但关于它们与产仔数关系的结果并不一致。本研究旨在采用荟萃分析方法研究山羊的 BMP15（g.735 G>A）和 KISS1（g.2540 C>T 和 g.2510 G>A）基因与产仔数之间的遗传关系。本次荟萃分析共纳入了 5 项关于 g.735 G>A 基因突变的研究（包括 12 个品种）、3 项关于 g.2540 C>T 基因突变的研究（包括 9 个品种）和 2 项关于 g.2510 G>A 基因突变的研究（包括 6 个品种）。荟萃分析在四种不同的遗传模式下进行：隐性遗传（GG + AG 与 AA）、显性遗传（GG 与 AG + AA）、加性遗传（GG 与 AA）和共显性遗传（GG + AA 与 AG）。根据 I2 估计值，在随机或固定效应模型下对数据进行分析。为了确定总体结果的稳定性，每次删除一项研究进行敏感性分析。漏斗图和 Egger 回归检验也用于评估研究之间的发表偏倚。在加性遗传模型（SMD = -0.469，95 % CI = -0.908至-0.030，P值 = 0.036）和共显性遗传模型（SMD = 0.147，95 % CI = 0.003至0.291，P = 0.046）下，分别观察到g.2540 C>T和g.2510 G>A位点与山羊产仔数之间存在显著关联（P< 0.05）。我们的结果表明，在所研究的遗传模型中，BMP15的g.735 G>A与窝产仔数之间没有明显的关联。

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来源期刊

Animal Reproduction Science 农林科学-奶制品与动物科学

CiteScore

4.50

自引率

9.10%

发文量

136

审稿时长

54 days

期刊介绍： Animal Reproduction Science publishes results from studies relating to reproduction and fertility in animals. This includes both fundamental research and applied studies, including management practices that increase our understanding of the biology and manipulation of reproduction. Manuscripts should go into depth in the mechanisms involved in the research reported, rather than a give a mere description of findings. The focus is on animals that are useful to humans including food- and fibre-producing; companion/recreational; captive; and endangered species including zoo animals, but excluding laboratory animals unless the results of the study provide new information that impacts the basic understanding of the biology or manipulation of reproduction. The journal''s scope includes the study of reproductive physiology and endocrinology, reproductive cycles, natural and artificial control of reproduction, preservation and use of gametes and embryos, pregnancy and parturition, infertility and sterility, diagnostic and therapeutic techniques. The Editorial Board of Animal Reproduction Science has decided not to publish papers in which there is an exclusive examination of the in vitro development of oocytes and embryos; however, there will be consideration of papers that include in vitro studies where the source of the oocytes and/or development of the embryos beyond the blastocyst stage is part of the experimental design.