Julian Furtado Silva, William Moraes de Souza, Juliana Delgado Campos Mello, Hugo Dugolin Ceccato, Priscilla de Sene Portel Oliveira, Maria de Lourdes Setsuko Ayrizono, Raquel Franco Leal
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引用次数: 0
Abstract
Objective: To conduct a systematic review (SR) to find evidence for a connection between Crohn's disease (CD) and the gut-brain axis (GBA).
Methods: This study conducted a systematic review (SR) employing a search strategy and strict inclusion criteria. It was conducted by searching for studies published between 2017 and 2024 in the following databases: PUBMED, PUBMED PMC, BVS-BIREME, SCOPUS, WEB OF SCIENCE, EMBASE, and COCHRANE.
Results: Fifty original research articles were included. Among these, 20 studies addressed neuroimaging methods to evaluate CD patients' functional or structural brain changes. Neurodegenerative diseases were the second most addressed topic in the studies, with 18 articles related to different diseases such as Parkinson's disease, Alzheimer's disease, dementia, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Multiple System Atrophy. Eight articles addressed sleep disorders related to CD; two explored Electroencephalography changes; one investigated Brain-Derived Neurotrophic Factor serum levels and one correlated vagotomy with CD.
Conclusion: Interest in the link between CD and GBA is increasing, but studies remain varied and inconclusive, spanning from epidemiology to brain imaging and neglecting to investigate a mechanistic relationship. This SR underscores the need for further research to better understand the potential role of GBA in the prognosis and etiology of CD, highlighting its complexity.
目的进行系统综述（SR），寻找克罗恩病（CD）与肠脑轴（GBA）之间存在联系的证据：本研究采用检索策略和严格的纳入标准进行了系统综述（SR）。本研究采用检索策略和严格的纳入标准进行了系统性综述（SR），在以下数据库中检索了 2017 年至 2024 年间发表的研究：PUBMED、PUBMED PMC、BVS-BIREME、SCOPUS、WEB OF SCIENCE、EMBASE 和 COCHRANE：结果：共收录了 50 篇原创研究文章。结果：共收录了 50 篇原创研究文章，其中 20 篇研究采用神经影像学方法评估 CD 患者的大脑功能或结构变化。神经退行性疾病是第二大研究主题，有 18 篇文章涉及不同的疾病，如帕金森病、阿尔茨海默病、痴呆症、肌萎缩侧索硬化症、多发性硬化症和多系统萎缩症。八篇文章讨论了与 CD 有关的睡眠障碍；两篇文章探讨了脑电图的变化；一篇文章调查了脑源性神经营养因子的血清水平；一篇文章将迷走神经切断术与 CD 相关联：结论：人们对 CD 和 GBA 之间联系的兴趣与日俱增，但研究仍然多种多样，没有定论，研究范围从流行病学到脑成像，忽略了对机理关系的研究。本研究强调了进一步研究的必要性，以更好地了解 GBA 在 CD 的预后和病因学中的潜在作用，突出了其复杂性。
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