Evidence of SARS-CoV-2 Spread in Rural Tanzania During the First 6 Months of the Global COVID-19 Pandemic.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

American Journal of Tropical Medicine and Hygiene Pub Date : 2024-11-12 DOI:10.4269/ajtmh.23-0784

Srijana B Chhetri, Daniel Nance, Mwajabu Loya, Caleb Cornaby, Alena J Markmann, John L Schmitz, Jessica T Lin, Billy Ngasala

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引用次数: 0

Abstract

In the first 6 months of the coronavirus disease 2019 pandemic, limited testing clouded understanding of the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in Africa. In particular, Tanzania halted all testing and reporting of SARS-CoV-2 cases after May 2020, not resuming until June 2021. In July-August 2020, we performed a seroprevalence survey in rural Bagamoyo district, 40 km outside Dar es Salaam. Among 347 asymptomatic children and adults, 64/347 (18.0%) demonstrated seroreactivity to SARS-CoV-2 spike receptor binding domain by ELISA. Given significant antibody cross-reactivity in malaria-endemic regions, seropositivity was additionally confirmed via a multitarget Luminex immunoassay. Thirty-seven, or 58% of initially seroreactive persons, were Luminex positive, leading to an estimated SARS-CoV-2 seroprevalence of 10.7% (37/347, 95% CI 7.6-14.4%). Working in health care appeared to be associated with seropositivity. Reporting of viral symptoms or health care-seeking behavior in the previous 3 months was not more frequent in seropositive individuals.

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在全球 COVID-19 大流行的前 6 个月，SARS-CoV-2 在坦桑尼亚农村地区传播的证据。

在冠状病毒疾病 2019 年大流行的前 6 个月，有限的检测使人们对非洲严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）传播范围的了解变得模糊不清。特别是，坦桑尼亚在 2020 年 5 月后停止了所有 SARS-CoV-2 病例的检测和报告，直到 2021 年 6 月才恢复。2020 年 7 月至 8 月，我们在达累斯萨拉姆郊外 40 公里处的巴加莫约区农村进行了血清流行率调查。在 347 名无症状的儿童和成人中，64/347（18.0%）人通过 ELISA 检测出对 SARS-CoV-2 穗状受体结合域有血清反应。鉴于疟疾流行地区存在明显的抗体交叉反应，血清阳性还需通过多目标 Luminex 免疫测定法进行确认。在最初血清反应阳性者中，有 37 人（占 58%）的 Luminex 呈阳性，因此估计 SARS-CoV-2 的血清流行率为 10.7%（37/347，95% CI 7.6-14.4%）。从事医疗保健工作似乎与血清阳性有关。血清反应阳性者在过去 3 个月中报告病毒症状或寻求医疗保健服务的频率并不高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.20

自引率

3.00%

发文量

508

审稿时长

3 months

期刊介绍： The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries