Pharmacological modulation of respiratory control: Ampakines as a therapeutic strategy

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Sabhya Rana , Anna F. Fusco , Jeffrey M. Witkin , Daniel P. Radin , Rok Cerne , Arnold Lippa , David D. Fuller
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引用次数: 0

Abstract

Ampakines are a class of compounds that are positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and enhance glutamatergic neurotransmission. Glutamatergic synaptic transmission and AMPA receptor activation are fundamentally important to the genesis and propagation of the neural impulses driving breathing, including respiratory motoneuron depolarization. Ampakines therefore have the potential to modulate the neural control of breathing. In this paper, we describe the influence of ampakines on respiratory motor output in health and disease. We dissect the molecular mechanisms underlying ampakine action, delineate the diverse targets of ampakines along the respiratory neuraxis, survey the spectrum of respiratory disorders in which ampakines have been tested, and culminate with an examination of how ampakines modulate respiratory function after spinal cord injury. Collectively, the studies reviewed here indicate that ampakines may be a useful adjunctive strategy to pair with conventional respiratory rehabilitation approaches in conditions with impaired neural activation of the respiratory muscles.
呼吸控制的药理调节:安非他酮作为一种治疗策略。
安帕金森类化合物是α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA)受体的正异位调节剂,能增强谷氨酸能神经传递。谷氨酸能突触传递和 AMPA 受体激活对于驱动呼吸(包括呼吸运动神经元去极化)的神经冲动的产生和传播至关重要。因此,安巴碱有可能调节呼吸的神经控制。在本文中,我们描述了安帕金在健康和疾病情况下对呼吸运动输出的影响。我们剖析了安帕金作用的分子机制,沿着呼吸神经轴线划分了安帕金的不同靶点,调查了安帕金已被测试过的各种呼吸系统疾病,最后研究了安帕金如何调节脊髓损伤后的呼吸功能。总之,本文回顾的研究表明,在呼吸肌神经激活受损的情况下,安帕金可能是一种有用的辅助策略,可与传统的呼吸康复方法搭配使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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