Case-control study of otoconia proteins otolin-1 and otoconin-90 in patients with Meniere's disease.

IF 1.2 4区医学 Q3 OTORHINOLARYNGOLOGY

Acta Oto-Laryngologica Pub Date : 2024-11-09 DOI:10.1080/00016489.2024.2423661

Weiwei Han, Qinfeng Wu, Yunqin Wu, Xiaoxiong Lu, Lulu Li, Kewang Zhou, Weinv Fan

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引用次数: 0

Abstract

Backgrounds: Otolin-1 and otoconin-90, the main otoconia matrix protein, can pass through the labyrinth-blood barrier and are detectable in the peripheral blood. Previous studies have shown that serum levels of these proteins well reflect otolith status, but none of concerning Meniere's disease (MD).

Objectives: This study aimed to evaluate the serum levels of otolin-1 and otoconin-90 in patients with MD.

Material and methods: Patients with MD confirmed during an acute episode, and age- and sex-matched controls were recruited. Their demographic and clinical data were recorded. The serum levels of otolin-1 and otoconin-90 were measured and compared.

Results: A total of 33 patients with MD and 176 healthy controls were recruited. In patients with MD, the median otolin-1 level was 284.96 pg/mL (interquartile range [IQR] 208.65-331.49 pg/mL) and the median otoconin-90 level was 60.50 ng/mL (IQR 40.61-85.62 ng/mL), which were significantly higher than those in the control group (p < 0.0001 and p = 0.005, respectively). Among patients with MD, serum otoconin-90 levels were correlated with the MD clinical grade (ρ = 0.487, p = 0.04), whereas serum otoconin-1 levels were not (ρ = 0.327, p = 0.063).

Conclusions: Serum levels of otolin-1 and otoconin-90 may serve as biomarkers of otolith lesions in patients with MD.

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梅尼埃病患者耳声蛋白 otolin-1 和 otoconin-90 的病例对照研究。

背景：耳石素-1 和耳石素-90 是主要的耳石基质蛋白，可通过迷宫-血液屏障并在外周血中检测到。以前的研究表明，这些蛋白的血清水平能很好地反映耳石的状态，但没有一项研究涉及梅尼埃病（MD）：本研究旨在评估梅尼埃病患者血清中耳石素-1 和耳石素-90 的水平：材料和方法：招募急性发作期间确诊的 MD 患者以及年龄和性别匹配的对照组。记录他们的人口统计学和临床数据。结果：共有 33 名 MD 患者和年龄与性别相匹配的对照组患者：结果：共招募了 33 名 MD 患者和 176 名健康对照者。在 MD 患者中，otolin-1 水平的中位数为 284.96 pg/mL（四分位距 [IQR] 208.65-331.49 pg/mL），otoconin-90 水平的中位数为 60.50 ng/mL（IQR 40.61-85.62 ng/mL），均显著高于对照组（p p = 0.005）。在 MD 患者中，血清耳可宁-90 水平与 MD 临床分级相关（ρ = 0.487，p = 0.04），而血清耳可宁-1 水平与 MD 临床分级无关（ρ = 0.327，p = 0.063）：结论：血清中耳石素-1和耳石素-90的水平可作为MD患者耳石病变的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Oto-Laryngologica 医学-耳鼻喉科学

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Acta Oto-Laryngologica is a truly international journal for translational otolaryngology and head- and neck surgery. The journal presents cutting-edge papers on clinical practice, clinical research and basic sciences. Acta also bridges the gap between clinical and basic research.