Chlorophenols in environment: Recent updates on pretreatment and analysis methods

Abstract

Chlorophenols (CPs) are widely used in industries such as petrochemicals, insecticides, pharmaceuticals, synthetic dyes and wood preservatives. However, owing to the improper discharge and disposal, they have become major contaminants that are ubiquitously distributed in water, soil, and sewage sediments, posing a significant threat to ecosystems and human health. Consequently, accurate, sensitive and effective pretreatment and analysis methods for CPs are urgently required and have been actively explored in recent years. This review encompasses the pretreatment and detection methods for CPs in environmental samples from 2010 to 2024. The pretreatment methods for CPs primarily include solid-phase extraction, liquid-liquid extraction, solid-phase microextraction, liquid-phase microextraction, and QuEChERS. These methods are evolving towards more effective and environmentally friendly technologies, such as the miniaturization and automation of equipment, the development of innovative materials (including graphene, molecularly imprinted polymers, layered double hydroxides, porous organic polymers, and porous carbon), and the use of green solvents like deep eutectic solvents. Detection methods emphasize liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, sensors, and capillary electrophoresis. Advances in chromatographic columns, novel ion sources, and high-resolution mass spectrometry have significantly improved detection performance. In addition, the pros and cons of diverse techniques, critical comments and future perspectives are elaborated.