Metabolism, mitochondria and metastasis in kidney cancer

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-11-13 DOI:10.1038/s41585-024-00968-7

Louise Lloyd

引用次数: 0

Abstract

A study published in Nature investigating tumour metabolism in kidney cancers provides insight into the influence of mitochondria and cellular metabolism on metastasis in this disease.

In this study, a ¹³C-labelled nutrient, [U-¹³C]glucose, was administered through a peripheral intravenous line to patients with varying subtypes of renal cell carcinoma (RCC) undergoing partial or radical nephrectomy during their surgery. Overall, 59 patients, 37 of whom had clear cell RCC (ccRCC), were included.

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肾癌的代谢、线粒体和转移

自然》（Nature）杂志发表的一项研究对肾癌的肿瘤代谢进行了调查，该研究深入探讨了线粒体和细胞代谢对肾癌转移的影响。在这项研究中，我们通过外周静脉注射给接受肾部分或根治性切除术的不同亚型肾细胞癌（RCC）患者注射了13C标记的营养物质--[U-13C]葡萄糖。共纳入了 59 名患者，其中 37 人患有透明细胞肾癌（ccRCC）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.