Cardiodermatology: the heart of the connection between the skin and cardiovascular disease

IF 41.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Joel M. Gelfand, William B. Song, Sinéad M. Langan, Michael S. Garshick
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Abstract

The skin and cardiovascular systems are connected in unique and meaningful ways, and many diseases conventionally considered as being limited to one organ system are more closely related than previously believed. Major cardiovascular diseases and phenomena such as infective endocarditis, congestive heart failure, Kawasaki disease and thromboembolism are associated with specific skin findings, and advances in genetics, immunology and clinical epidemiology show that inflammatory dermatological diseases, such as psoriasis, have serious cardiovascular and cardiometabolic consequences. Additionally, commonly used cardiovascular therapies, such as antihypertensive medications, are associated with important cutaneous adverse effects, including photosensitivity, photocarcinogenesis and eczematous skin reactions. Moreover, systemic dermatological therapies, including retinoids, Janus kinase inhibitors and biologics, can alter the risk of cardiovascular and cardiometabolic diseases. In this Review on cardiodermatology, we provide interdisciplinary insights from dermatology and cardiology that will be of practical use to both cardiologists and generalists who manage cardiovascular and cardiometabolic diseases in patients with dermatological findings or histories. We discuss specific skin findings associated with cardiovascular diseases to aid in diagnosis; important cutaneous adverse effects of common cardiovascular therapies, for the purpose of treatment monitoring; and the effect of dermatological diseases and dermatological treatment on cardiovascular risk.

Abstract Image

心脏皮肤病学:皮肤与心血管疾病之间的核心联系
皮肤和心血管系统以独特而有意义的方式联系在一起,许多传统上被认为仅限于一个器官系统的疾病比以前认为的更加密切相关。主要的心血管疾病和现象,如感染性心内膜炎、充血性心力衰竭、川崎病和血栓栓塞等,都与特定的皮肤发现有关。遗传学、免疫学和临床流行病学的进展表明,炎症性皮肤病,如银屑病,会对心血管和心脏代谢造成严重后果。此外,常用的心血管疗法,如抗高血压药物,与重要的皮肤不良反应有关,包括光敏性、光致癌性和皮肤湿疹反应。此外,包括维甲酸、Janus 激酶抑制剂和生物制剂在内的全身性皮肤疗法也会改变心血管疾病和心脏代谢疾病的风险。在这篇有关心脏皮肤病学的综述中,我们提供了皮肤病学和心脏病学的跨学科见解,这些见解对心脏病学家和普通医生治疗有皮肤病发现或病史的心血管和心脏代谢疾病患者都有实际帮助。我们将讨论与心血管疾病相关的特定皮肤发现,以帮助诊断;常见心血管疗法的重要皮肤不良反应,以监测治疗;以及皮肤病和皮肤病治疗对心血管风险的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Reviews Cardiology
Nature Reviews Cardiology 医学-心血管系统
CiteScore
53.10
自引率
0.60%
发文量
143
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.
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