Deep Eutectic Solvents for Essential-Oil Delivery and Bacterial-Infected Wound Healing

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2024-10-31 DOI:10.1021/acs.langmuir.4c0273610.1021/acs.langmuir.4c02736

Yaping Liu, Di Wang, Yaoyao Lai, Jiahui Zou, Pei Yang, Zhenfeng Wu* and Wei He*,

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引用次数: 0

Abstract

Essential oils (EOs) are volatile secondary metabolites of natural plants with multitudinous pharmacological activities. However, limited by their properties, such as low solubility, high volatility, photothermal instability, irritation, release, etc., EOs encounter significant challenges in pharmaceutical applications. Deep eutectic solvents (DESs) have been developed for the transdermal delivery of biomolecules and lipid-soluble drugs. Herein, a series of DES carriers were synthesized to improve the undesirable properties of EOs. We first optimized the DESs according to solubilization and aqueous dispersity using Chimonanthus nitens Oliv. EO (COEO) as a model EO. Then, the EO–DES formulations were diluted to prepare optimal aqueous EO–DES nanoformulations (AqEDs). Mechanically, hydrogen bonding allowed the DES to dissolve the complex components in EOs; meanwhile, the interaction forces, such as π–π stacking and hydrogen bonding, drove the EO–DES to assemble into nanostructures in aqueous conditions, forming AqEDs. Lastly, a case study demonstrated that clove EO-AqEDscould effectively promote methicillin-resistant Staphylococcus aureus-infected wound healing in vivo, along with biocompatibility. This AqED strategy provides a generalized platform for solubilizing EOs and improving their transdermal/topical delivery.

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用于精油输送和细菌感染伤口愈合的深层共晶溶剂

精油（EOs）是天然植物的挥发性次级代谢产物，具有多种药理活性。然而，由于受到低溶解度、高挥发性、光热不稳定性、刺激性、释放等特性的限制，精油在制药应用中遇到了巨大挑战。深共晶溶剂（DES）已被开发用于生物大分子和脂溶性药物的透皮给药。在此，我们合成了一系列 DES 载体，以改善环氧乙烷的不良特性。首先，我们以Chimonanthus nitens Oliv.环氧乙烷（COEO）作为模型环氧乙烷。然后，将环氧乙烷-DES制剂稀释，制备出最佳的环氧乙烷-DES纳米水性制剂（AqEDs）。从机理上讲，氢键作用使DES能够溶解EO中的复杂成分；同时，π-π堆积和氢键等相互作用力促使EO-DES在水性条件下组装成纳米结构，形成AqEDs。最后，一项案例研究表明，丁香环氧乙烷-AqEDs 能有效促进耐甲氧西林金黄色葡萄球菌感染的伤口在体内愈合，并具有生物相容性。这种 AqED 策略为增溶环氧乙烷和改善其透皮/局部给药提供了一个通用平台。

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).