Microbubble Enhanced Delivery of Vitamin C for Treatment of Colorectal Cancer

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-10-30 DOI:10.1021/acsomega.4c0677910.1021/acsomega.4c06779

Joseph Fox, Damien V. B. Batchelor, Patricia Louise Coletta, Elizabeth M.A. Valleley and Stephen D. Evans*,

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Abstract

During chemotherapy treatment for cancer, often only a fraction of the administered dose reaches the tumor site, with the remaining drug spreading throughout the body, producing unwanted side-effects and restricting how much drug can be safely administered. A potential solution to reduce this problem is the use of microbubbles. The interaction between microbubbles and ultrasound generates pores in the tumor cells, permitting enhanced drug uptake. This study investigates the delivery of the ascorbic acid derivative, palmitoyl ascorbate, to KRAS-mutated colorectal cancer cells in vitro. Ultrasound-triggered microbubbles enhanced the efficacy of liposomal palmitoyl ascorbate treatments by 1.7- and 2.2-fold in LS174T and HCT116 CRC cell lines, respectively. This enhancement was achieved without increasing the drug dosage, and the therapeutic effect was shown to be localized to the area that received the ultrasound pulse, aiding in the reduction of off-site toxicity.

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用微气泡增强维生素 C 的输送以治疗结直肠癌

在癌症化疗过程中，往往只有一小部分给药剂量能到达肿瘤部位，剩余的药物会扩散到全身，产生不必要的副作用，并限制了可安全给药的剂量。减少这一问题的潜在解决方案是使用微气泡。微气泡和超声波之间的相互作用会在肿瘤细胞中产生孔隙，从而提高药物吸收率。本研究调查了抗坏血酸衍生物--抗坏血酸棕榈酰酯在体外向 KRAS 突变的结直肠癌细胞递送药物的情况。在 LS174T 和 HCT116 CRC 细胞系中，超声触发的微气泡分别将抗坏血酸棕榈酰脂质体的疗效提高了 1.7 倍和 2.2 倍。这种提高是在不增加药物剂量的情况下实现的，而且治疗效果被证明只局限于接受超声脉冲的区域，有助于减少异位毒性。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567