Prussian Blue Nanostructure Conjugated Berberine Improves Inflammatory Response of Rheumatoid Arthritis by Suppressing Necroptosis

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-10-20 DOI:10.1021/acsanm.4c0446610.1021/acsanm.4c04466

Yuan Wang, Fang Xu, Yixuan Wang, Xinran Hu, Baofeng Zhao, Sen Lin* and Xifan Mei*,

引用次数: 0

Abstract

Rheumatoid arthritis has serious consequences for human health. Drugs can relieve the symptoms of some patients, but they exert significant toxic side effects. We loaded berberine into the Prussian blue nanostructure, synthesizing BRB-PB composites. It improves photothermal properties and exhibits potent anti-inflammatory and antioxidant effects. BRB-PB composites inhibited RIPK1/RIPK3/MLKL signaling pathway activation in RA synovial tissue, suggesting a unique molecular mechanism that reduces the occurrence of necroptosis and improves RA symptoms. Rapid metabolism and excellent biocompatibility of BRB-PB composites enhanced their safety and efficacy.

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普鲁士蓝纳米结构共轭小檗碱通过抑制坏死改善类风湿性关节炎的炎症反应

类风湿性关节炎对人类健康造成严重影响。药物可以缓解部分患者的症状，但会产生明显的毒副作用。我们在普鲁士蓝纳米结构中加入小檗碱，合成了小檗碱-普鲁士蓝复合材料。它改善了光热特性，并表现出强大的抗炎和抗氧化作用。BRB-PB复合材料可抑制RA滑膜组织中RIPK1/RIPK3/MLKL信号通路的激活，这表明它具有独特的分子机制，可减少坏死的发生并改善RA症状。BRB-PB复合材料的快速代谢和良好的生物相容性提高了其安全性和有效性。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.