Bimetallic Cu@Co-MOFs Mimic Peroxidase for Colorimetric Detection of Glutathione

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-10-17 DOI:10.1021/acsanm.4c0456310.1021/acsanm.4c04563

Yaohua Gu, Jiping Han, Ni Zhang, Weisong Yan, Yue Guo, Huiyi Tan, Changyi Yang*, Fuke Wang* and Huiqin Yao*,

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Abstract

Nanozyme possess the advantages of high enzyme simulation activity, low cost, and excellent stability. As a substitute for natural enzymes, nanozyme have demonstrated significant potential in various fields. In this study, a bimetallic organometallic framework Cu@Co-MOFs was synthesized via the hydrothermal method using terephthalic acid (H₂BDC) as a ligand and characterized. Cu@Co-MOFs exhibits outstanding peroxidase activity (POD) by catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) and other color-developing substrates through •OH formation. A simple, rapid, and reliable colorimetric method for quantitatively detecting glutathione (GSH) was developed based on the Pod-like activity of Cu@Co-MOFs. The linear range of this method was 1–1200 μM with a detection limit of 0.72 μM. This work not only proposes a bimetallic organic framework with high POD as a straightforward and practical platform for visually detecting GSH but also provides a strategy to enhance the performance of nanomaterials.

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双金属 Cu@Co-MOFs 可模拟过氧化物酶，用于比色检测谷胱甘肽

纳米酶具有酶模拟活性高、成本低、稳定性好等优点。作为天然酶的替代品，纳米酶在各个领域都表现出了巨大的潜力。本研究以对苯二甲酸（H2BDC）为配体，通过水热法合成了双金属有机金属框架 Cu@Co-MOFs，并对其进行了表征。Cu@Co-MOFs 通过-OH 的形成催化 3,3′,5,5′-四甲基联苯胺（TMB）和其他显色底物的氧化，表现出卓越的过氧化物酶活性（POD）。基于 Cu@Co-MOFs 的荚状活性，开发了一种简单、快速、可靠的定量检测谷胱甘肽（GSH）的比色法。该方法的线性范围为 1-1200 μM，检测限为 0.72 μM。这项工作不仅提出了一种具有高 POD 的双金属有机框架作为可视化检测 GSH 的直接实用平台，而且为提高纳米材料的性能提供了一种策略。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.