Recent progress and current status of surface engineered magnetic nanostructures in cancer theranostics

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science Pub Date : 2024-10-28 DOI:10.1016/j.cis.2024.103320

Bijaideep Dutta , K.C. Barick , P.A. Hassan , A.K. Tyagi

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Abstract

Cancer theranostic is the combination of diagnosis and therapeutic modalities for cancer treatment. It realizes a more flexible, precise and non-invasive treatment of patients. In this aspect, magnetic nanostructures (MNSs) have gained paramount importance and revolutionized the cancer management due to their unique physicochemical properties and inherent magnetic characteristics. MNSs have amazing theranostic ability starting from drug delivery to magnetic hyperthermia and magnetic resonance imaging to multimodal imaging in association with radioisotopes or fluorescent probes. Precise regulation over the synthetic process and their consequent surface functionalization makes them even more fascinating. The ultimate goal is to develop a platform that combines multiple diagnostic and therapeutic functionalities based on MNSs. This perspective has provided an overview of the state-of-art of theranostic applications of MNSs. Special emphasis has been dedicated towards the importance of synthetic approaches of MNSs as well as their subsequent surface engineering and integration with biological/therapeutic molecules that decide the final outcomes of the efficacy of MNSs in theranostic applications. Moreover, the recent advancements, opportunities and allied challenges towards clinical applications of MNSs in cancer management have been demonstrated.

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表面工程磁性纳米结构在癌症治疗中的最新进展和现状。

癌症疗法是将诊断和治疗方式相结合的癌症治疗方法。它能对病人进行更灵活、精确和无创的治疗。在这方面，磁性纳米结构（MNSs）因其独特的物理化学特性和固有的磁性特征，在癌症治疗领域获得了极其重要的地位并带来了革命性的变化。磁性纳米结构具有惊人的治疗能力，从药物递送到磁热疗，从磁共振成像到与放射性同位素或荧光探针结合的多模式成像。对合成过程的精确调控以及随之而来的表面功能化使它们更加迷人。我们的最终目标是开发一个基于 MNS 的平台，将多种诊断和治疗功能结合起来。本视角概述了 MNS 治疗应用的最新进展。其中特别强调了 MNS 合成方法的重要性，以及随后的表面工程和与生物/治疗分子的整合，这决定了 MNS 在治疗学应用中的最终疗效。此外，还展示了 MNS 在癌症治疗中临床应用的最新进展、机遇和相关挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.