Can minor trauma cause asymptomatic cervical spinal cord compression leading to severe cervical spinal cord injury in rats?

IF 1.6 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2024-11-06 DOI:10.1097/WNR.0000000000002113

Luchun Xu, Ting Wang, Zheng Cao, Yushan Gao, Guozheng Jiang, Yukun Ma, Jiawei Song, Yongdong Yang, Xing Yu

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引用次数: 0

Abstract

The study aimed to determine whether asymptomatic rats with cervical spinal cord compression (CSCC) experience more severe cervical spinal cord injury (SCI) compared with rats without CSCC under the same degree of minor trauma. Four weeks after the polyvinyl alcohol-polyacrylamide hydrogel was implanted into the C5 vertebral canal, asymptomatic rats were selected based on locomotor function score. Mild cervical SCI was subsequently established based on CSCC. The motor function, morphology, neuron loss, myelin destruction, nerve cell apoptosis, microglia activation, and neuroinflammation were evaluated after SCI. Under the same injury conditions, rats in the CSCC group exhibited more severe motor dysfunction compared with those without CSCC. Similarly, asymptomatic CSCC rats showed significant damage to spinal cord tissue, neurons, and myelin. Finally, compared with rats without CSCC, asymptomatic CSCC rats experienced increased nerve cell apoptosis, microglial activation, and neuroinflammation following the same SCI. In asymptomatic CSCC rats, the same degree of minor trauma resulted in more severe cervical SCI compared with rats without CSCC. This was evidenced by increased nerve cell apoptosis, microglial activation, neuron death, myelin destruction, and a strong neuroinflammatory response, leading to severe motor dysfunction.

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轻微外伤会导致大鼠无症状性颈椎脊髓压迫，从而导致严重的颈椎脊髓损伤吗？

该研究旨在确定在相同程度的轻微创伤下，无症状的颈脊髓压迫（CSCC）大鼠与无CSCC大鼠相比是否会经历更严重的颈脊髓损伤（SCI）。将聚乙烯醇-聚丙烯酰胺水凝胶植入 C5 椎管四周后，根据运动功能评分选择无症状大鼠。随后根据 CSCC 确定轻度颈椎 SCI。对 SCI 后大鼠的运动功能、形态、神经元丢失、髓鞘破坏、神经细胞凋亡、小胶质细胞活化和神经炎症进行了评估。在相同的损伤条件下，CSCC组大鼠比无CSCC组大鼠表现出更严重的运动功能障碍。同样，无症状的 CSCC 大鼠的脊髓组织、神经元和髓鞘也出现了明显的损伤。最后，与未患 CSCC 的大鼠相比，无症状 CSCC 大鼠在同样的 SCI 损伤后，神经细胞凋亡、小胶质细胞活化和神经炎症均有所增加。与无 CSCC 的大鼠相比，无症状的 CSCC 大鼠在遭受同等程度的轻微创伤后，颈椎 SCI 会更加严重。这表现为神经细胞凋亡增加、小胶质细胞活化、神经元死亡、髓鞘破坏和强烈的神经炎症反应，从而导致严重的运动功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.