Post-Discharge Growth Among Extremely Preterm Infants With or Without Bronchopulmonary Dysplasia.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI:10.1002/ppul.27388

Yasuka Kimoto, Katsuya Hirata, Shinya Hirano, Kazuko Wada, Akinori Moriichi, Yoshiya Ito, Kazutoshi Cho, Katsumi Mizuno, Katsuaki Toyoshima, Reiko Kushima, Nozomi Ishii, Takeshi Yamaguchi, Keiji Hashimoto, Yukari Yada, Yumi Kono

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引用次数: 0

Abstract

Objective: This study aimed to evaluate whether bronchopulmonary dysplasia (BPD) and home respiratory care (HRC) after discharge, including home oxygen therapy (HOT) or home mechanical ventilation (HMV), were associated with the growth of extremely preterm infants.

Study design: This secondary study uses data from a study on the infant and early childhood development survey of low-birth-weight infants in the Health, Labor, and Welfare Science Research. We enrolled 788 singleton extremely preterm infants appropriate for gestational age (GA). BPD was defined as the requirement of supplemental oxygen or respiratory support at 36 weeks corrected GA. We compared trends of anthropometric measurements from age 0 to 5 years among infants with non-BPD, BPD without HRC, and BPD with HRC.

Results: We obtained 4113 weight and length measurements. At age 0-5 years, the BPD with the HRC group weighed less and was shorter than the other two groups. Lower GA and BPD status were significantly associated with growth failure of weight at 3 and 5 years after adjustment for potential risk factors. Lower GA was significantly associated with growth failure of length at 3 and 5 years. Conversely, although BPD status was significantly associated with growth failure of length at 3 years, it was not at 5 years.

Conclusion: Among extremely preterm infants, BPD with HRC was associated with a significant growth delay at 0-5 years compared with non-BPD and BPD without HRC. However, the effect of different severities of BPD on growth failure of length was attenuated with age.

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患有或未患有支气管肺发育不良的极早产儿出院后的生长情况。

研究目的本研究旨在评估支气管肺发育不良（BPD）和出院后的家庭呼吸护理（HRC），包括家庭氧疗（HOT）或家庭机械通气（HMV），是否与极早产儿的生长发育有关：这项二次研究使用了《健康、劳动和福利科学研究》（Health, Labor, and Welfare Science Research）中一项关于低出生体重婴儿和幼儿发展调查的研究数据。我们招募了 788 名符合胎龄（GA）的单胎极早产儿。BPD的定义是在36周正确胎龄时需要补充氧气或呼吸支持。我们比较了非 BPD 婴儿、无 HRC 的 BPD 婴儿和有 HRC 的 BPD 婴儿从 0 到 5 岁的人体测量趋势：结果：我们共测量了 4113 个婴儿的体重和身长。在0-5岁时，有HRC的BPD组婴儿比其他两组婴儿体重更轻、身长更短。在对潜在风险因素进行调整后，较低的 GA 值和 BPD 状态与 3 岁和 5 岁时的体重增长失败有显著关联。GA 较低与 3 岁和 5 岁时的身长发育不良有明显关系。相反，虽然 BPD 状态与 3 岁时身长生长不良有显著相关性，但与 5 岁时身长生长不良无显著相关性：结论：在极早产儿中，与非 BPD 和无 HRC 的 BPD 婴儿相比，伴有 HRC 的 BPD 婴儿在 0-5 岁时会出现明显的生长迟缓。然而，不同严重程度的 BPD 对身长生长迟缓的影响随着年龄的增长而减弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.