Fluoxetine does not influence response to continuous theta burst stimulation in human motor cortex.

IF 2 Q3 NEUROSCIENCES
Neuropsychopharmacology Reports Pub Date : 2025-03-01 Epub Date: 2024-11-07 DOI:10.1002/npr2.12493
Duncan K Austin, Lourenço M D Amador, Lucia M Li, Simon J Little, John C Rothwell
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引用次数: 0

Abstract

Aim: Selective serotonin reuptake inhibitors are thought to exert a clinical effect through various mechanisms, including through alteration in synaptic plasticity. Repetitive transcranial magnetic stimulation can induce temporary changes in synaptic excitability in cerebral cortex that resemble long-term potentiation and long-term depression that serve as a measure of synaptic plasticity in vivo. A version of repetitive transcranial magnetic stimulation called continuous theta burst stimulation can induce inhibition of cortical excitability that can be measured through a motor evoked potential. Previous work has suggested that this response can be modulated by administration of selective serotonin reuptake inhibitors.

Method: Thirty-one healthy volunteers received both fluoxetine 20 mg and placebo in randomly ordered sessions, followed by spaced continuous theta burst stimulation to motor cortex. Changes in Motor Evoked Potentials were then recorded over 60 min.

Results: The response to spaced continuous theta burst stimulation did not differ significantly between fluoxetine and placebo sessions. Spaced continuous theta burst stimulation produced a paradoxical excitatory response in an unexpected number of participants.

Conclusion: A single dose of fluoxetine 20 mg does not influence the response to continuous theta burst stimulation. Previous results suggesting an effect of selective serotonin reuptake inhibitors on inhibitory non-invasive brain stimulation protocols may be due to insufficiently large sample sizes.

氟西汀不会影响人类运动皮层对连续θ脉冲刺激的反应。
目的:选择性5-羟色胺再摄取抑制剂被认为通过各种机制产生临床效果,包括通过改变突触可塑性。重复经颅磁刺激可诱导大脑皮层突触兴奋性的暂时性变化,这种变化类似于长期延时和长期抑制,可作为体内突触可塑性的衡量标准。重复经颅磁刺激的一种形式称为连续θ脉冲刺激,可诱导抑制大脑皮层的兴奋性,这种抑制可通过运动诱发电位进行测量。以前的研究表明,这种反应可以通过服用选择性血清素再摄取抑制剂来调节:方法:31 名健康志愿者随机接受 20 毫克氟西汀和安慰剂治疗,然后对运动皮层进行间隔的连续θ脉冲刺激。然后记录 60 分钟内运动诱发电位的变化:结果:氟西汀和安慰剂对间隔连续θ脉冲刺激的反应没有显著差异。结果:氟西汀和安慰剂对间隔连续θ脉冲刺激的反应没有显著差异:结论:单剂量 20 毫克氟西汀不会影响对连续θ脉冲刺激的反应。之前的研究结果表明选择性血清素再摄取抑制剂对抑制性非侵入性脑刺激方案有影响,这可能是由于样本量不够大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuropsychopharmacology Reports
Neuropsychopharmacology Reports Psychology-Clinical Psychology
CiteScore
3.60
自引率
4.00%
发文量
75
审稿时长
14 weeks
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