Prognostic and Immunotherapeutic Role of TACC3 in Pancancer, and its Impact on Proliferation and Docetaxel Resistance in Lung Adenocarcinoma.

IF 2.5 3区医学 Q3 ONCOLOGY

Oncology Pub Date : 2024-11-07 DOI:10.1159/000542450

Jianyu Xu, Ying Zhu, Qian Liu, Chenchang Xu, Wenjuan Wang, Jiantong Sun, Xinyuan Ding, Biao Liu, Lei Chen

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引用次数: 0

Abstract

Introduction: Transforming acidic coiled-coil containing protein 3 (TACC3) exerts a vital role in cancer progression by modulating cell division and facilitating tumor growth. Given the lack of comprehensive research on the pan-cancer implications of TACC3, our study aimed to analyze the functional role of TACC3 in pan-cancer and validate it through experimental investigations in lung adenocarcinoma.

Methods: We first employed various bioinformatics techniques to investigate the expression and prognostic significance of TACC3 in pancancer. Subsequently, we analyzed the correlation between TACC3 and immune infiltration, immune checkpoints, drug sensitivity, as well as the prediction of immune therapy response. Finally, we validated the association between TACC3 and the proliferation of lung adenocarcinoma, as well as its resistance to docetaxel, through in vitro experiments.

Results: Here, TACC3 exhibited high expression in human cancers and was associated with poor prognosis in various cancer types. It was also involved in immune infiltration and demonstrated a strong predictive ability for immune therapy response. Through drug sensitivity prediction, we further identified a potential association between TACC3 and docetaxel resistance, which was subsequently validated in lung adenocarcinoma.

Conclusion: Our investigation of TACC3 revealed its potential as a promising target both for immunosuppression and docetaxel resistance in pan-cancer, especially in lung adenocarcinoma.

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TACC3在胰腺癌中的预后和免疫治疗作用及其对肺腺癌增殖和多西他赛耐药性的影响

简介转化酸性盘旋线圈含蛋白3（TACC3）通过调节细胞分裂和促进肿瘤生长，在癌症进展中发挥着重要作用。鉴于缺乏对 TACC3 泛癌症影响的全面研究，我们的研究旨在分析 TACC3 在泛癌症中的功能作用，并通过肺腺癌的实验研究进行验证：我们首先利用各种生物信息学技术研究了TACC3在胰腺癌中的表达和预后意义。随后，我们分析了 TACC3 与免疫浸润、免疫检查点、药物敏感性以及免疫治疗反应预测之间的相关性。最后，我们通过体外实验验证了TACC3与肺腺癌的增殖及其对多西他赛的耐药性之间的关联：结果：TACC3在人类癌症中表现出高表达，并与各种癌症类型的不良预后有关。结果：在这里，TACC3 在人类癌症中表现出高表达，并与各种癌症类型的不良预后有关，它还参与了免疫浸润，并对免疫治疗反应表现出很强的预测能力。通过药物敏感性预测，我们进一步发现了TACC3与多西他赛耐药性之间的潜在关联，随后在肺腺癌中得到了验证：我们对TACC3的研究揭示了它作为泛癌症（尤其是肺腺癌）免疫抑制和多西他赛耐药靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.