Morphometric Measurements of the Incomplete Partition Type II (IP-II) Cochlea and Implications on Cochlear Implantation.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-08 DOI:10.1097/MAO.0000000000004370

Adam Y Xiao, Miryam Saad, Rance J T Fujiwara, Emily C Wong, Grant O Korte, Levent Sennaroglu, Ivan A Lopez, Gail Ishiyama, Akira Ishiyama

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Abstract

Hypothesis: The objective of this study is to obtain comprehensive morphometric measurements of the incomplete partition type II (IP-II) cochlea to provide a better understanding of intracochlear anatomy and important considerations for electrode selection and insertion.

Background: IP-II is the most common bony inner ear malformation that often requires cochlear implantation. Currently, there is significant controversy on electrode selection due to a lack of research that can provide reliable, high-resolution measurements.

Methods: Three-dimensional reconstructions of the cochlea were made from hematoxylin and eosin-stained slides from 11 archival human temporal bones from 8 adult IP-II patients (one paired) and 2 fetuses. Detailed measurements of the angular and linear length of the spiral ganglion neurons and cochlear duct at the modiolar and lateral wall of the scala tympani as well as cross-sectional areas and vertical height measurements of the scala tympani at 90-degree intervals were measured.

Results: The spiral ganglia neurons terminated at 540.5 ± 45.4 degrees, which corresponded to the beginning of the interscalar septal defect. The corresponding Rosenthal's canal length was 12.75 ± 0.82 mm, and the lateral wall length was 23.95 ± 1.04. The average cochlear duct length was 32.44 mm ± 1.58 mm, corresponding to an average angular distance of 951.6 ± 80 degrees. The modiolar height demonstrated less variation within the scala tympani but was significantly smaller at 0 and 90 degrees compared with the normal cochlea. The lateral wall height was also significantly smaller at 0, 180, and 540 degrees. There was a drastic decrease in lateral wall height at 540 degrees to 0.4 mm, which is smaller than the apical dimension of many electrodes.

Conclusion: This is the first study to provide detailed morphometric measurements of the IP-II cochlea including spiral ganglion neuron length and scala tympani height. These measurements directly relate to electrode selection for cochlear implantation.

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不完全分隔型 II (IP-II) 耳蜗的形态测量及其对人工耳蜗植入的影响。

假设：本研究的目的是对不完全分隔型 II（IP-II）耳蜗进行全面的形态测量，以便更好地了解耳蜗内的解剖结构以及电极选择和插入的重要注意事项：背景：IP-II 是最常见的骨性内耳畸形，通常需要植入人工耳蜗。背景：IP-II 是最常见的骨性内耳畸形，通常需要植入人工耳蜗。目前，由于缺乏能提供可靠、高分辨率测量的研究，在电极选择方面存在很大争议：方法：利用苏木精和伊红染色的切片对耳蜗进行三维重建，切片来自 11 块存档的人类颞骨，这些颞骨来自 8 名成年 IP-II 患者（一对）和 2 名胎儿。详细测量了螺旋神经节神经元和耳蜗导管在鼓室模和侧壁的角度和线性长度，以及鼓室的横截面积和90度间隔的垂直高度：结果：螺旋神经节神经元终止于 540.5 ± 45.4 度，与鳞隔间缺损的起始点相对应。相应的罗森塔尔管长度为 12.75 ± 0.82 毫米，侧壁长度为 23.95 ± 1.04 毫米。耳蜗导管的平均长度为 32.44 毫米 ± 1.58 毫米，对应的平均角距离为 951.6 ± 80 度。鼓室内的模小耳高度变化较小，但与正常耳蜗相比，0度和90度处的模小耳高度明显较小。侧壁高度在 0 度、180 度和 540 度时也明显较小。侧壁高度在 540 度时急剧下降至 0.4 毫米，小于许多电极的顶端尺寸：这是首次对 IP-II 型耳蜗进行详细形态测量，包括螺旋神经节神经元长度和鼓室高度。这些测量结果与人工耳蜗植入的电极选择直接相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.