Differential Plin5 response to high-fat diet in cardiomyocytes isolated from young and aged mice

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2024-11-06 DOI:10.1016/j.mad.2024.112004

Patricia Baumgarten , Tobias Jung , Christiane Ott , Tilman Grune

引用次数: 0

Abstract

This study investigates the differences in the heart response to an 8-week high-fat diet between young and aged mice. Isolated cardiomyocytes reveal a significant lower level in the lipid droplet-associated protein Plin5 in aged mice. High-fat diet, however, leads to an induction of Plin5 in aged mice and a low-response of lipid metabolism, whereas in cardiomyocytes from young animals the Plin5 level was largely unaffected by high-fat diet whereas several lipid metabolizing enzymes were induced. Therefore, the high-fat diet induced lipid droplet accumulation is more pronounced in cardiomyocytes isolated from aged animals.

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从年轻小鼠和老龄小鼠分离的心肌细胞对高脂肪饮食的不同 Plin5 反应。

本研究调查了年轻小鼠和老年小鼠对 8 周高脂肪饮食的心脏反应差异。分离的心肌细胞显示，老年小鼠的脂滴相关蛋白 Plin5 水平明显较低。然而，高脂饮食会导致诱导老年小鼠的 Plin5 和低反应的脂质代谢，而在年轻动物的心肌细胞中，Plin5 的水平基本不受高脂饮食的影响，而几种脂质代谢酶却被诱导。因此，高脂饮食诱导的脂滴积聚在分离自老年动物的心肌细胞中更为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.