Synthesis of heavy-atom-free thienoisoindigo dye as near-infrared photosensitizer for type I photodynamic therapy and photoacoustic imaging

IF 3.9 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of photochemistry and photobiology. B, Biology Pub Date : 2024-11-05 DOI:10.1016/j.jphotobiol.2024.113052

Feng Zhang , Hao Cai , Leichen Wang , Jinjun Shao

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引用次数: 0

Abstract

Thienoisoindigo (TIIG) has been extensively employed as promising building block of near-infrared (NIR) dyes and organic semiconductor materials. Herein, heavy-atom-free TIIG-based NIR dye TIIGTPA is reported as photosensitizer for combinational photodynamic and photothermal therapy and photoacoustic imaging (PAI). By introducing two methoxy-substituted triphenylamines as the rotors and electron donors at the periphery sites of the electron-deficient TIIG core, dye TIIGTPA featuring Donor-Acceptor-Donor (D-AD) structure is constructed with intensive NIR absorption. Through co-assembly with amphipathic F-127, water-soluble TIIGTPA NPs were prepared with good superoxide anion radical (O₂^-•) production and high photothermal conversion efficiency (PCE) of 59.0 % under 730 nm photoirradiation. Additionally, the excellent photothermal effect enabled a superior photoacoustic response for tumor blood vessel visualization through PAI. All results indicated the favorable potential of TIIGTPA NPs for PAI-mediated combinational phototherapy.

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合成不含重原子的噻吩异靛蓝染料，作为 I 型光动力疗法和光声成像的近红外光敏剂。

噻吩异靛蓝（TIIG）已被广泛用作近红外（NIR）染料和有机半导体材料的重要组成部分。本文报道了无重原子 TIIG 基近红外染料 TIIGTPA 作为光敏剂用于光动力和光热疗法以及光声成像（PAI）。通过在缺电子 TIIG 内核的外围位点引入两个甲氧基取代的三苯基胺作为转子和电子供体，构建了具有高强度近红外吸收的供体-受体-供体（D-AD）结构的染料 TIIGTPA。通过与两性离子 F-127 共同组装，制备出了水溶性 TIIGTPA NPs，在 730 纳米光照射下，该 NPs 具有良好的超氧阴离子自由基（O2--）生成能力和 59.0 % 的高光热转换效率（PCE）。此外，卓越的光热效应还能通过 PAI 实现肿瘤血管可视化的卓越光声响应。所有结果都表明，TIIGTPA NPs 在 PAI 介导的组合光疗中具有良好的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of photochemistry and photobiology. B, Biology 生物-生化与分子生物学

CiteScore

12.10

自引率

1.90%

发文量

161

审稿时长

37 days

期刊介绍： The Journal of Photochemistry and Photobiology B: Biology provides a forum for the publication of papers relating to the various aspects of photobiology, as well as a means for communication in this multidisciplinary field. The scope includes: - Bioluminescence - Chronobiology - DNA repair - Environmental photobiology - Nanotechnology in photobiology - Photocarcinogenesis - Photochemistry of biomolecules - Photodynamic therapy - Photomedicine - Photomorphogenesis - Photomovement - Photoreception - Photosensitization - Photosynthesis - Phototechnology - Spectroscopy of biological systems - UV and visible radiation effects and vision.