Isotretinoin Combined Laser/Light-Based Treatments Versus Isotretinoin Alone for the Treatment of Acne Vulgaris: A Meta-Analysis.

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2024-11-07 DOI:10.1111/jocd.16639

Shi-Xin He, Yi Wang, Jun Wang, Li Tang, Li Yang, Fei-Lun Ye

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引用次数: 0

Abstract

Objectives: This study aims to compare the efficacy and safety of oral isotretinoin with and without laser/light-based treatments for acne.

Methods: This study was conducted under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines; this meta-analysis utilized data from PubMed, EMBASE, ClinicalTrial.gov, and the Cochrane Central Register of Controlled Trials until December 2023. We evaluated clinical improvement, lesion reduction, adverse events, as well as intraoperative and postoperative discomfort rates. Analyses were performed using Review Manager 5.3.

Results: This review included six articles with a total of 285 patients. Isotretinoin combined with laser/light therapy outperformed in clinical improvement rates, significantly reducing acne vulgaris and acne scars lesions compared to isotretinoin alone. Additionally, there was no significant difference in the incidence of adverse events between the two groups.

Conclusion: The study suggests that combining isotretinoin with laser/light-based therapy for acne yields superior efficacy and satisfaction without increased complications (e.g., dryness, hyperpigmentation, and scarring). However, patients experience notable treatment-related discomfort.

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异维A酸联合激光/光疗与单用异维A酸治疗痤疮：元分析。

研究目的本研究旨在比较口服异维A酸与激光/光治疗痤疮的疗效和安全性：本研究根据《系统综述和荟萃分析首选报告项目》（Preferred Reporting Items for Systematic Reviews and Meta-Analyses，PRISMA）指南进行；本荟萃分析使用的数据来自 PubMed、EMBASE、ClinicalTrial.gov 和 Cochrane Central Register of Controlled Trials，截止日期为 2023 年 12 月。我们评估了临床改善、病灶缩小、不良事件以及术中和术后不适率。我们使用Review Manager 5.3进行了分析：本综述包括六篇文章，共涉及 285 名患者。与单独使用异维A酸相比，异维A酸联合激光/光疗的临床改善率更高，能显著减少寻常型痤疮和痤疮疤痕的皮损。此外，两组患者的不良反应发生率没有明显差异：该研究表明，将异维A酸与激光/光疗法结合治疗痤疮可获得更好的疗效和满意度，同时不会增加并发症（如干燥、色素沉着和瘢痕）。不过，患者会有明显的治疗相关不适感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.