Leveraging Implementation Factors and Policy to Improve the Effectiveness of Naloxone.

IF 4.2 3区医学 Q1 SUBSTANCE ABUSE

Journal of Addiction Medicine Pub Date : 2024-11-08 DOI:10.1097/ADM.0000000000001406

Ashly E Jordan, Mary Brewster, Pamela Mund, Grace Hennessy, Chinazo O Cunningham

引用次数: 0

Abstract

Abstract: More than 50 years of high-quality data demonstrate that naloxone is an efficacious and cost-effective overdose reversal agent. Intranasal naloxone is now available in the United States as an over-the-counter and generic medication for the first time since the start of the overdose crisis more than 20 years ago. As the overdose crisis continues to contribute to substantial loss of life, there is an historic opportunity for jurisdictions to expand equitable and sustained access to intranasal naloxone. Further, through simultaneously enacting and expanding effective Naloxone Access and Good Samaritan laws, and equitably implementing these laws, there is the potential to maximize the population-level effectiveness of naloxone to sustainably reduce overdose mortality.

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利用实施因素和政策提高纳洛酮的有效性。

摘要：50 多年的高质量数据表明，纳洛酮是一种有效且具有成本效益的用药过量逆转剂。自 20 多年前吸毒过量危机爆发以来，美国首次以非处方药和普通药的形式提供鼻内注射纳洛酮。由于用药过量危机继续造成大量人员伤亡，各辖区面临着扩大鼻内纳洛酮公平、持续获取途径的历史性机遇。此外，通过同时颁布和扩大有效的纳洛酮使用和好撒玛利亚人法律，并公平地实施这些法律，有可能最大限度地提高纳洛酮在人群中的有效性，从而持续降低用药过量死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Addiction Medicine 医学-药物滥用

CiteScore

6.10

自引率

9.10%

发文量

260

审稿时长

>12 weeks

期刊介绍： The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.